Chlorotriisopropylsilane
Chlorotriisopropylsilane (CAS 13154-24-0), with the linear formula [(CH3)2CH]3SiCl and a molecular weight of 192.80 g/mol, is a valuable organosilicon compound. It serves as a versatile reagent in organic synthesis, particularly for silylation reactions. Its robust structure makes it useful for protecting sensitive functional groups and in analytical applications such as derivatization for chromatography. Tech Serve Solutions supplies this chemical for research and synthesis purposes.
- IUPAC
- Silane IP3,TIPSCl,Triisopropylchlorosilane,Triisopropylsilyl chloride
- Synonyms
- TriisopropylchlorosilaneTriisopropylsilyl chlorideTIPSClSilane, chlorotriisopropyl-
![Chlorotriisopropylsilane ([(CH3)2CH]3SiCl) — chemical structure, CAS 13154-24-0; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F13154-24-0.png&w=3840&q=75)
Silylating Agent
Chlorotriisopropylsilane is widely employed as a silylating agent in organic synthesis. It is used to introduce the triisopropylsilyl (TIPS) protecting group onto alcohols, amines, and other nucleophilic functional groups, enhancing their stability or modifying their reactivity during multi-step syntheses.
Protecting Group Chemistry
The TIPS group, readily installed by chlorotriisopropylsilane, offers excellent steric bulk and stability, making it suitable for protecting reactive intermediates in complex synthetic pathways. It can be selectively removed under specific conditions, facilitating intricate molecular construction.
Chromatographic Derivatization
In analytical chemistry, chlorotriisopropylsilane can be used to derivatize compounds for gas chromatography (GC) or high-performance liquid chromatography (HPLC). Silylation often increases volatility and thermal stability, improving chromatographic separation and detection of analytes.
Organic Synthesis Reagent
As a general synthetic reagent, chlorotriisopropylsilane finds application in various organosilicon chemistry transformations. Its predictable reactivity allows for controlled reactions in the development of new materials and complex organic molecules.
| Molecular weight | 192.80 |
|---|---|
| Linear formula | [(CH3)2CH]3SiCl |
| Assay | ≥97.0% (GC) |
| Grade | purum |
| Boiling point | 198 °C/739 mmHg(lit.) |
| Density | 0.901 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.452(lit.) |
| Vapour pressure | 1.16 mmHg (20 °C) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 64 °C / 147.2 °F |
| Transport (UN / ADR) | UN 2987 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chlorotriisopropylsilane primarily used for?
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Chlorotriisopropylsilane (CAS 13154-24-0) is primarily used as a silylating agent in organic synthesis for introducing the bulky triisopropylsilyl (TIPS) protecting group, and in analytical chemistry for derivatization purposes.
What is the CAS number and chemical formula for Chlorotriisopropylsilane?
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The CAS number for Chlorotriisopropylsilane is 13154-24-0. Its linear formula is [(CH3)2CH]3SiCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Chlorotriisopropylsilane with a purity of ≥97.0% (GC), designated as purum grade. We do not represent this product as USP, BP, or EP grade.
How should Chlorotriisopropylsilane be handled safely?
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Chlorotriisopropylsilane is a corrosive substance (H314) that causes severe skin burns and eye damage. Handle with appropriate personal protective equipment, including chemical-resistant gloves, safety goggles, a face shield, and suitable respiratory protection, in a well-ventilated area. Refer to the Safety Data Sheet for detailed handling instructions.
How is Chlorotriisopropylsilane packed, shipped, and exported?
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Chlorotriisopropylsilane is packed and shipped according to stringent international regulations for hazardous materials, ensuring safe transport globally. As an experienced exporter, TSS handles all necessary documentation and compliance for international shipments.
How can I request a quote or sample of Chlorotriisopropylsilane?
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To request a quote or a sample of Chlorotriisopropylsilane, please contact our sales team through the website or by phone, providing your contact details and the quantity required.
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