2-Chloro-3-(difluoromethyl)pyridine
2-Chloro-3-(difluoromethyl)pyridine (CAS: 865663-96-3, C6H4ClF2N) is a halogenated heterocyclic compound with a molecular weight of 163.55 g/mol. It serves as a valuable building block in organic synthesis, particularly for the creation of complex molecules in the pharmaceutical and agrochemical industries. Its specific structure allows for targeted chemical modifications, making it a useful intermediate for research and development purposes.

Pharmaceutical Intermediate
This compound acts as a key building block in the synthesis of novel pharmaceutical agents. Its halogenated pyridine structure is amenable to various coupling and functionalization reactions, facilitating the development of drug candidates.
Agrochemical Synthesis
Used in the development of advanced agrochemicals, 2-Chloro-3-(difluoromethyl)pyridine contributes to the creation of new crop protection agents. Its unique difluoromethyl and chloro substitutions offer potential for enhanced biological activity.
Organic Synthesis Reagent
As a versatile reagent in organic chemistry, it enables the construction of complex heterocyclic frameworks. Researchers utilise its reactivity profile for exploring new synthetic pathways and creating diverse chemical libraries.
| Molecular weight | 163.55 |
|---|---|
| Empirical formula | C6H4ClF2N |
| Assay | 95% |
| Density | 1.388 g/mL at 25 °C |
| Refractive index | n20/D 1.491 |
| Storage temperature | 2-8°C |

Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Flash point | 80 °C / 176 °F |
|---|---|
| Transport (UN / ADR) | UN 2810 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-36/37/38 |
| Safety statements (S) | 26-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-3-(difluoromethyl)pyridine used for?
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2-Chloro-3-(difluoromethyl)pyridine (CAS: 865663-96-3) is primarily used as a building block in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. Its specific structural features make it a valuable intermediate for creating more complex molecules.
What are the CAS number and formula for 2-Chloro-3-(difluoromethyl)pyridine?
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The CAS number for 2-Chloro-3-(difluoromethyl)pyridine is 865663-96-3, and its molecular formula is C6H4ClF2N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloro-3-(difluoromethyl)pyridine with a purity of 95% (assay). This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Chloro-3-(difluoromethyl)pyridine be handled safely?
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This compound is classified as Danger, with hazard statements including H301 (Toxic if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment in a well-ventilated area, following precautionary statements P261, P301 + P310, and P305 + P351 + P338.
Is 2-Chloro-3-(difluoromethyl)pyridine eligible for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. 2-Chloro-3-(difluoromethyl)pyridine can be packed and shipped internationally, subject to all relevant regulations.
How can I request a sample or quote for this chemical?
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To request a sample or a quotation for 2-Chloro-3-(difluoromethyl)pyridine, please contact our sales department through the provided channels on the Tech Serve Solutions website.
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