Bromoacetic acid N-hydroxysuccinimide ester
Bromoacetic acid N-hydroxysuccinimide ester (CAS: 42014-51-7) is a heterobifunctional cross-linking reagent with a molecular weight of 236.02 g/mol. This compound facilitates the bromoacetylation of primary amines, followed by coupling to sulfhydryl-containing molecules, forming stable thioether bonds. It is primarily utilised in chemical biology and synthesis for applications such as protein modification and structural analysis.
Heterobifunctional Cross-linking
This reagent enables the formation of stable cross-links between molecules containing primary amine and sulfhydryl groups. The reaction proceeds in two stages: initial bromoacetylation of amines, followed by thioether bond formation with thiols.
Protein Modification
It can be used to covalently modify proteins by targeting specific amino acid residues. This is valuable in biochemical research for studying protein structure, function, and interactions.
Chemical Synthesis
As a versatile building block, it assists in the synthesis of more complex molecules in organic and medicinal chemistry laboratories.
Bioconjugation
The compound's ability to link different biomolecules makes it useful in bioconjugation strategies for developing assays or targeted delivery systems.
| Molecular weight | 236.02 |
|---|---|
| Empirical formula | C6H6BrNO4 |
| Assay | ≥95% |
| Form | powder |
| Solubility | acetone: soluble25 mg/mLDMF: soluble |
| Storage temperature | −20°C |
| Application | A heterobifunctional cross-linking reagent which allows bromoacetylation of primary amine groups followed by coupling to sulfhydryl-containing compounds. Typically, initial reaction couples via ester to primary amine by amide bond formation in the pH range 6.5-8.5. The second reaction results in thioether bonding in pH range 7.0-8.0. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Quality Level | PREMIUM |
|---|---|
| Shipped In | dry ice |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bromoacetic acid N-hydroxysuccinimide ester used for?
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Bromoacetic acid N-hydroxysuccinimide ester is a heterobifunctional cross-linking reagent used for bromoacetylation of primary amine groups and subsequent coupling to sulfhydryl-containing compounds, facilitating thioether bond formation in chemical biology and synthesis.
What is the CAS number and molecular formula?
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The CAS number is 42014-51-7 and the molecular formula is C6H6BrNO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical at a purity of ≥95% with a PREMIUM quality level. It is not represented as USP, BP, EP, or other pharmacopoeial grade.
How should Bromoacetic acid N-hydroxysuccinimide ester be handled safely?
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Handle with appropriate personal protective equipment, including a dust mask (N95 US type), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. Refer to the Safety Data Sheet for comprehensive guidance.
How is this chemical shipped and stored?
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This product is shipped in dry ice and should be stored at −20°C.
How can I request a sample or quote?
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Please contact our sales department via the website or by phone to request a sample or a quotation for Bromoacetic acid N-hydroxysuccinimide ester.
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