BrettPhos
BrettPhos (CAS: 1070663-78-3), a sophisticated organophosphorus compound with the molecular formula C35H53O2P and a molecular weight of 536.77 g/mol, is a highly effective phosphine ligand. It is primarily employed in palladium-catalyzed cross-coupling reactions, such as the Buchwald-Hartwig amination, and has also found utility in fluorination processes. This compound is supplied by TSS for advanced chemical synthesis and research applications.
- IUPAC
- 2-(Dicyclohexylphosphino)3,6-dimethoxy-2′,4′,6′-triisopropyl-1,1′-biphenyl
Buchwald-Hartwig Amination
BrettPhos serves as a crucial ligand in palladium-catalyzed Buchwald-Hartwig amination reactions. This application facilitates the formation of carbon-nitrogen bonds, vital in the synthesis of pharmaceuticals and complex organic molecules.
Fluorination Reactions
This phosphine ligand is also recognised for its efficacy in various fluorination methodologies. Its use enables precise introduction of fluorine atoms into organic structures, a key transformation in medicinal chemistry.
Palladium-Catalyzed Cross-Coupling
As a specialised Buchwald ligand, BrettPhos is instrumental in a range of palladium-catalyzed cross-coupling reactions. It promotes efficient bond formation, contributing to streamlined synthetic routes in organic chemistry.
| Molecular weight | 536.77 |
|---|---|
| Empirical formula | C35H53O2P |
| Assay | 96% |
| Application | Buchwald Phosphine Ligands for chemical Synthesis |
| Melting point | 187-195 °C |
| Ligand For | Buchwald-Hartwig Cross Coupling ReactionFluorinations |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is BrettPhos primarily used for?
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BrettPhos is primarily used as a phosphine ligand in palladium-catalyzed cross-coupling reactions, including the Buchwald-Hartwig amination and various fluorination reactions, supporting advanced chemical synthesis.
What is the CAS number and molecular formula for BrettPhos?
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The CAS number for BrettPhos is 1070663-78-3, and its molecular formula is C35H53O2P.
What grade and purity does Tech Serve Solutions supply for BrettPhos?
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Tech Serve Solutions supplies BrettPhos with an assay of 96%. We do not represent this product as USP, BP, or EP grade.
How should BrettPhos be handled and stored?
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The safety data indicates BrettPhos is not classified as hazardous according to German WGK classification. However, standard laboratory precautions should be observed. Store in a cool, dry place away from incompatible materials. Please refer to the Safety Data Sheet (SDS) for comprehensive handling information.
How can I request a quote or sample for BrettPhos?
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To request a quote or sample of BrettPhos, please contact our sales team via the website or by telephone. Our team will be happy to assist with your inquiry.
Does Tech Serve Solutions export BrettPhos?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including BrettPhos, serving customers worldwide.
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