(+)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid
(+)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid (CAS 61696-54-6), a derivative of the crown ether 18-crown-6, has a molecular weight of 440.35 g/mol. This chiral compound is notable for its utility in synthesising chiral captands and its application as a chiral selector in capillary electrophoresis. It is supplied by TSS with an assay of 97%.
- IUPAC
- (2R,3R,11R,12R)-1,4,7,10,13,16-Hexaoxacyclooctadecane-2,3,11,12-tetracarboxylic acid
- Synonyms
- 12-tetracarboxylic acid, 61696-54-6, C16H24O14, (2R,3R,11R,12R)-1,4,7,10,13,16-Hexaoxacyclooctadecane-2,3,11,12-tetracarboxylic acid
Synthesis of Chiral Captands
The tetracarboxylic acid chloride derived from this crown ether is used to react with meta- and para-xylylene diamines, yielding chiral captands with high efficiency. This process is crucial for creating complex chiral molecules.
Chiral Selector in Capillary Electrophoresis
This compound serves as an effective chiral selector in capillary zone electrophoresis. It facilitates the separation of various optically active amines, aiding in enantiomeric analysis.
Monoamide Synthesis
It is employed in the synthesis of monoamides, a class of organic compounds with diverse applications in chemical research and development.
| Molecular weight | 440.35 |
|---|---|
| Empirical formula | C16H24O14 |
| Assay | 97% |
| Optical activity | [α]20/D +62°, c = 1 in methanol |
| Application | Derived tetracarboxylic acid chloride of this crown ether reacts with meta- and para-xylylene diamines to form chiral captands in high yields.1 Used as a chiral selector in capillary zone electrophoresis for the separation of a variety of optically active amines.2 Synthesis of monoamides.3 |
| Melting point | 210-212 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid primarily used for?
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(+)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid is primarily used for the synthesis of chiral captands, as a chiral selector in capillary electrophoresis for separating optically active amines, and in the synthesis of monoamides.
What are the CAS number and molecular formula for this compound?
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The CAS number is 61696-54-6, and the empirical formula (Hill notation) is C16H24O14.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid with an assay of 97%. TSS does not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid be handled?
+
This compound is classified as a Warning substance (GHS07) and may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Use a type N95 dust mask, eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. In case of eye contact, rinse cautiously with water for several minutes (P305 + P351 + P338).
Is this chemical suitable for food or pharmaceutical applications?
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The provided data indicates this is a 97% assay chemical. It is not specified as USP, BP, EP, or any other pharmacopoeia or food grade. Therefore, it should be considered for laboratory and chemical synthesis applications where this purity is suitable.
How is this chemical supplied and exported by TSS?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. This compound is packaged and shipped according to industry standards for chemical reagents, suitable for international export.
How can I request a quote or sample?
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To request a quote or a sample of (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid, please visit the Tech Serve Solutions website or contact our sales department directly.
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