Brefeldin A

CAS 20350-15-6C16H24O4Biochemicals & Reagents

Brefeldin A (CAS: 20350-15-6, C16H24O4, MW: 280.36) is a potent inhibitor of protein transport, affecting Golgi apparatus morphology and function. Isolated from Penicillium brefeldianum, this compound is a valuable tool in cell biology research for studying intracellular trafficking and endoplasmic reticulum stress. Its cytotoxic properties also make it a subject of interest in cancer research.

IUPAC: γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone,Ascotoxin,BFA,Cyanein,Decumbin
Synonyms: γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactoneAscotoxinBFACyaneinDecumbin

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Brefeldin A (C16H24O4) — chemical structure, CAS 20350-15-6; Life Science, fine chemical supplied by Tech Serve Solutions

AntibacterialAntibioticsAntibiotics A to ZAntibiotics A-FAntibiotics by ApplicationAntitumor AgentsBiochemicals and ReagentsCancer ResearchCell BiologyChemical Structure Class

01 /Applications

Cell Biology Research

Brefeldin A is widely used to investigate protein transport and the dynamics of the Golgi apparatus and endoplasmic reticulum. It disrupts vesicle trafficking, providing insights into cellular secretory pathways.

Cancer Research

Due to its cytotoxic effects and influence on cellular processes, Brefeldin A is employed in cancer research to study antineoplastic mechanisms and potential therapeutic applications.

Chemical Biology Tool

As a specific inhibitor of ER stress and protein transport, Brefeldin A serves as a key reagent for probing cell signaling pathways and the effects of protein accumulation within the cell.

02 /Properties

Molecular weight	280.36
Empirical formula	C16H24O4
Assay	≥99% (HPLC and TLC)
Solubility	ethanol: soluble1-5 mg/mL (Store stock solutions at -20 °C.)methanol: soluble10 mg/mL (Store stock solutions at -20 °C.)
Storage temperature	2-8°C
Biological source	from Penicillium brefeldianum

03 /Safety & handling

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H301Toxic if swallowed

Precautionary statements

P301IF SWALLOWED

Protective equipment	dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Transport (UN / ADR)	UN 2811 6.1 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

20350-15-6

MDL number

MFCD12913297

PubChem substance

24278285

Beilstein registry

25191

05 /Additional specifications

Quality Level	PREMIUM

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Brefeldin A used for?

Brefeldin A is primarily used as a research tool in cell biology to study protein transport, Golgi apparatus function, and endoplasmic reticulum stress. It also has applications in cancer research due to its cytotoxic properties.

What are the CAS number and formula for Brefeldin A?

The CAS number for Brefeldin A is 20350-15-6, and its molecular formula is C16H24O4.

What grade and purity does Tech Serve Solutions supply for Brefeldin A?

Tech Serve Solutions supplies Brefeldin A at a PREMIUM quality level with an assay of ≥99% (HPLC and TLC). We do not represent this product as USP, BP, or EP grade.

How should Brefeldin A be handled and stored?

Brefeldin A is classified as toxic if swallowed (H301) and requires careful handling. Use a dust mask (N95), eyeshields, faceshields, and gloves. Store at 2-8°C.