Buspirone hydrochloride
Buspirone hydrochloride (CAS: 33386-08-2), with the molecular formula C21H31N5O2 · HCl and a molecular weight of 421.96, is a selective serotonin 5-HT1A receptor agonist. It is widely recognised for its anxiolytic properties. This compound is a valuable research chemical and potential therapeutic agent, primarily investigated for its effects on the central nervous system and neurotransmission.
- IUPAC
- N-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride

Anxiolytic Research
Investigated for its efficacy in managing anxiety disorders, primarily by acting as a partial agonist at serotonin 5-HT1A receptors.
Neuroscience Research
Utilised in studies focusing on neurotransmission, particularly serotonergic pathways, and their role in mood regulation and behaviour.
GPCR Modulation Studies
Serves as a tool compound for exploring the function and modulation of G protein-coupled receptors (GPCRs), specifically the 5-HT1A receptor subtype.
| Molecular weight | 421.96 |
|---|---|
| Empirical formula | C21H31N5O2 · HCl |
| Storage temperature | 2-8°C |

Hazard statements
- H301Toxic if swallowed
Precautionary statements
- P301IF SWALLOWED
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25 |
| Safety statements (S) | 45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... HTR1A(3350) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Buspirone hydrochloride used for?
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Buspirone hydrochloride is primarily used in scientific research, particularly in neuroscience and pharmacology, for investigating anxiety, neurotransmission, and G protein-coupled receptor modulation.
What are the CAS number and formula for Buspirone hydrochloride?
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The CAS number for Buspirone hydrochloride is 33386-08-2, and its empirical formula is C21H31N5O2 · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Buspirone hydrochloride with a purity suitable for research and development purposes. Please refer to the product's specification sheet for detailed analytical data. TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades.
What are the primary safety concerns when handling Buspirone hydrochloride?
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Buspirone hydrochloride is classified with GHS06 and the signal word 'Danger'. It has hazard statement H301, indicating it is toxic if swallowed. Appropriate personal protective equipment should be worn, and handling should occur in a well-ventilated area. Refer to the Safety Data Sheet for full handling instructions.
How is Buspirone hydrochloride shipped?
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Buspirone hydrochloride is typically stored at 2-8°C. It is packed and exported by TSS in compliance with all relevant shipping regulations for chemical compounds.
How can I request a sample or quote for Buspirone hydrochloride?
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To request a sample or quote for Buspirone hydrochloride, please contact our sales team through the website or by phone, providing your specific requirements.
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