3,4-Difluorophenylacetylene
3,4-Difluorophenylacetylene (CAS: 143874-13-9) is an organic compound with the molecular formula C8H4F2 and a molecular weight of 138.11 g/mol. This terminal alkyne features a difluorinated phenyl ring, making it a valuable building block in organic synthesis. It is frequently employed in the creation of complex molecules within the pharmaceutical and agrochemical industries, serving as a versatile intermediate for introducing fluorinated alkynyl moieties.
- IUPAC
- 4-Ethynyl-1,2-difluorobenzene
- Synonyms
- 4-Ethynyl-1,2-difluorobenzene
Pharmaceutical Intermediate
Utilised in the synthesis of novel drug candidates, leveraging its difluorinated phenylacetylene structure for targeted molecular design and improved pharmacokinetic properties.
Agrochemical Synthesis
Serves as a key building block for developing new pesticides and herbicides, where the incorporation of fluorine can enhance biological activity and stability.
Materials Science
Can be incorporated into polymers or advanced materials where the unique electronic properties imparted by the difluorinated phenylacetylene group are desired.
Organic Synthesis Reagent
A versatile reagent for various coupling reactions, cyclizations, and other transformations in academic and industrial research settings.
| Molecular weight | 138.11 |
|---|---|
| Empirical formula | C8H4F2 |
| Assay | 90% |
| Density | 1.144 g/mL at 25 °C |
| Refractive index | n20/D 1.4902 |
Hazard statements
- H225Highly flammable liquid and vapour
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 7 °C / 44.6 °F |
| Transport (UN / ADR) | UN 1993BE 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F |
| Risk statements (R) | 11 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,4-Difluorophenylacetylene used for?
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3,4-Difluorophenylacetylene is primarily used as a building block and intermediate in organic synthesis, particularly for creating fluorinated compounds within the pharmaceutical and agrochemical sectors.
What is the CAS number and molecular formula for 3,4-Difluorophenylacetylene?
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The CAS number is 143874-13-9 and the molecular formula is C8H4F2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,4-Difluorophenylacetylene with a minimum assay of 90%. We do not represent this product as USP, BP, or EP grade.
How should 3,4-Difluorophenylacetylene be handled safely?
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3,4-Difluorophenylacetylene is a highly flammable liquid and vapour (H225). Handling requires strict adherence to safety protocols, including the use of appropriate personal protective equipment such as eyeshields, gloves, and a suitable respirator, and working in well-ventilated areas away from ignition sources.
How is 3,4-Difluorophenylacetylene packed and shipped?
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3,4-Difluorophenylacetylene is packed in compliance with UN 1993 regulations for flammable liquids (Class 3, PG II) and is exported globally by Tech Serve Solutions.
How can I request a sample or quote for 3,4-Difluorophenylacetylene?
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Please contact our sales team via the website or direct email to request a sample or a competitive quote for 3,4-Difluorophenylacetylene.
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