3,4-Difluorophenylboronic acid
3,4-Difluorophenylboronic acid (CAS 168267-41-2) is an organoboron compound with the molecular formula F2C6H3B(OH)2 and a molecular weight of 157.91 g/mol. This disubstituted aryl boronic acid serves as a valuable building block in organic synthesis. It is primarily employed as a reactant in various cross-coupling reactions, facilitating the formation of complex organic molecules.
- IUPAC
- 3,4-Difluorobenzeneboronic acid
- Synonyms
- F2C6H3B(OH)23,4-Difluorobenzeneboronic acid
Suzuki Cross-Coupling Reactions
3,4-Difluorophenylboronic acid is frequently utilised in Suzuki-Miyaura cross-coupling reactions with aryl and heteroaryl halides. This application allows for the efficient synthesis of biaryl compounds and other complex organic structures.
Liebeskind-Srogl Cross-Coupling
This compound can participate in oxo-directing Liebeskind-Srogl cross-coupling reactions. It reacts with gem-dihaloolefin-type α-oxo ketene dithioacetals to form specific carbon-carbon bonds.
Substitution Reactions with Enyne Acetates
3,4-Difluorophenylboronic acid is also applied in substitution reactions involving enyne acetates and carbonates. These reactions enable the introduction of the 3,4-difluorophenyl moiety into various organic frameworks.
| Molecular weight | 157.91 |
|---|---|
| Linear formula | F2C6H3B(OH)2 |
| Application | Reactant involved in:• Suzuki cross-coupling reactions with aryl and heteroaryl halides1,2• Oxo directing Liebeskind-Srogl cross-coupling reactions with gem-dihaloolefin-type α-oxo ketene dithioacetals3• Substitution reactions with enyne acetates and carbonates4 |
| Melting point | 305-310 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,4-Difluorophenylboronic acid used for?
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3,4-Difluorophenylboronic acid is used as a reactant in Suzuki cross-coupling reactions with aryl and heteroaryl halides, oxo directing Liebeskind-Srogl cross-coupling reactions with gem-dihaloolefin-type α-oxo ketene dithioacetals, and substitution reactions with enyne acetates and carbonates.
What is the CAS number and formula for 3,4-Difluorophenylboronic acid?
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The CAS number is 168267-41-2 and the linear formula is F2C6H3B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound for research and chemical synthesis purposes. Purity details are available on the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.
How should 3,4-Difluorophenylboronic acid be handled safely?
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It is important to wear eyeshields and gloves when handling 3,4-Difluorophenylboronic acid. A type N95 (US) or type P1 (EN143) respirator filter should be used if airborne exposure is possible. It is classified under WGK 2 in Germany.
Is 3,4-Difluorophenylboronic acid a controlled substance?
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Based on the provided data, there is no indication that 3,4-Difluorophenylboronic acid is a controlled substance.
How is 3,4-Difluorophenylboronic acid packed and exported?
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Tech Serve Solutions, a global supplier and exporter since 1998, ensures appropriate packaging for safe transit and export of chemicals worldwide.
How can I request a quote or sample?
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Please contact our sales department through the website to request a quote or a sample of 3,4-Difluorophenylboronic acid.
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