Boc-Ile-OH
N-(tert-Butoxycarbonyl)-L-isoleucine (Boc-Ile-OH), CAS 13139-16-7, is a protected amino acid derivative with the molecular formula CH3CH2CH(CH3)CH(COOH)NHCOOC(CH3)3 and a molecular weight of 231.29 g/mol. It serves as a crucial building block in peptide synthesis and organic chemistry. This compound is widely employed in research and development for creating complex peptides and as an intermediate in the synthesis of biologically active molecules and pharmaceuticals. Its protected nature facilitates controlled peptide chain elongation.
- IUPAC
- N-(tert-Butoxycarbonyl)-L-isoleucine,Boc-L-isoleucine
- Synonyms
- N-(tert-Butoxycarbonyl)-L-isoleucine, Boc-L-isoleucine
Peptide Synthesis
Boc-Ile-OH is a key intermediate in solid-phase and solution-phase peptide synthesis. The tert-butoxycarbonyl (Boc) protecting group on the amine allows for selective coupling reactions, enabling the controlled addition of L-isoleucine residues into peptide chains.
Pharmaceutical Intermediates
This protected amino acid derivative finds application in the synthesis of various pharmaceutical compounds. It acts as a chiral building block for creating complex drug molecules, particularly those incorporating isoleucine moieties.
Organic Synthesis
Beyond peptide and pharmaceutical applications, Boc-Ile-OH is utilized in general organic synthesis. Its defined stereochemistry and protecting group strategy make it valuable for constructing intricate organic structures and exploring new synthetic methodologies.
Research and Development
In academic and industrial research, Boc-Ile-OH is employed for exploring novel biochemical pathways, developing new catalytic processes, and investigating structure-activity relationships of peptides and peptidomimetics.
| Molecular weight | 231.29 |
|---|---|
| Linear formula | CH3CH2CH(CH3)CH(COOH)NHCOOC(CH3)3 |
| Assay | 98% |
| Optical activity | [α]20/D +2.7°, c = 2 in acetic acid |
| Melting point | 66-69 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Boc-Ile-OH used for?
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Boc-Ile-OH is primarily used as a protected amino acid building block in peptide synthesis, a chiral intermediate in pharmaceutical synthesis, and in general organic chemistry research.
What is the CAS number and molecular formula for Boc-Ile-OH?
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The CAS number for Boc-Ile-OH is 13139-16-7, and its linear formula is CH3CH2CH(CH3)CH(COOH)NHCOOC(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Boc-Ile-OH with an assay of 98%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated in the product specifications.
How should Boc-Ile-OH be handled and stored?
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Handle Boc-Ile-OH with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or P1 (EN143) respirator filter is recommended. Store in a cool, dry place away from incompatible materials.
Is Boc-Ile-OH a controlled substance?
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Based on the provided data, Boc-Ile-OH is not indicated as a controlled substance.
How is Boc-Ile-OH packed and shipped?
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Tech Serve Solutions exports chemicals globally. Specific packing and shipping details will be provided upon request, adhering to all relevant transport regulations.
How can I request a quote or sample for Boc-Ile-OH?
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Please contact our sales team or use the online inquiry form to request a quote or a sample of Boc-Ile-OH.
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