Boc-Asp(OMe)-fluoromethyl ketone

CAS 187389-53-3C11H18NO5FBiochemicals & Reagents

Boc-Asp(OMe)-fluoromethyl ketone (CAS: 187389-53-3, Formula: C11H18NO5F) is a synthetic organic compound with a molecular weight of 263.26 g/mol. This fluoromethyl ketone derivative of N-alpha-tert-butoxycarbonyl-L-aspartic acid 5-methyl ester is specifically designed as a cell-permeable caspase inhibitor. It is primarily utilized in biochemical research to study apoptosis and related cellular processes.

IUPAC: Boc-D-FMK

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Boc-Asp(OMe)-fluoromethyl ketone (C11H18NO5F) — chemical structure, CAS 187389-53-3; Life Science, fine chemical supplied by Tech Serve Solutions

A to CApoptosis EnzymesApoptosis and Cell CycleApplication IndexBioactive Small MoleculesBiochemicals and ReagentsCaspaseCaspase InhibitorsCaspasesCaspases (general)

01 /Applications

Caspase Inhibition

Boc-Asp(OMe)-fluoromethyl ketone functions as a potent inhibitor of caspases, a family of cysteine proteases critical for initiating and executing apoptosis. Its methyl ester form enhances cell permeability, allowing for intracellular target engagement in biological studies.

Apoptosis Research

This compound is a valuable tool for researchers investigating the mechanisms of programmed cell death. By inhibiting specific caspases, it helps elucidate their roles in various physiological and pathological conditions, including cancer and neurodegenerative diseases.

Cell Biology Studies

Utilised in cell biology laboratories, Boc-Asp(OMe)-fluoromethyl ketone aids in the study of cell signaling pathways and cellular responses. Its application helps to dissect the complex cascade of events involved in cell survival and death.

02 /Properties

Molecular weight	263.26
Empirical formula	C11H18NO5F
Assay	≥90% (TLC)
Form	solid
Storage temperature	−20°C
Application	Caspase inhibitor designed as a methyl ester to facilitate cell permeability.

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

187389-53-3

MDL number

MFCD03453073

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Boc-Asp(OMe)-fluoromethyl ketone used for?

Boc-Asp(OMe)-fluoromethyl ketone is used as a cell-permeable caspase inhibitor primarily for research into apoptosis and cell signaling pathways.

What are the CAS number and formula for Boc-Asp(OMe)-fluoromethyl ketone?

The CAS number is 187389-53-3, and the empirical formula is C11H18NO5F.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Boc-Asp(OMe)-fluoromethyl ketone with an assay of ≥90% (TLC). This product is intended for research purposes and is not represented as USP, BP, or EP grade.

What are the safety and handling precautions for Boc-Asp(OMe)-fluoromethyl ketone?

Handling this compound requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The WGK (Germany) is 3, indicating a hazard to water.