Bleomycin sulfate from Streptomyces verticillus

CAS 9041-93-4Biochemicals & Reagents

Bleomycin sulfate, derived from Streptomyces verticillus and identified by CAS 9041-93-4, is a lyophilized white powder. This glycopeptide antibiotic is primarily utilised in research for its tumour-specific cytotoxic activity and its role in studying free radical-mediated DNA strand scission. It is also employed as a selection agent in genetic engineering, particularly for plant transformants, with a recommended concentration range of 10-100 μg/ml.

IUPAC: Blenoxane,Bleo,Blexane

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Bleomycin sulfate from Streptomyces verticillus — chemical structure, CAS 9041-93-4; Life Science, fine chemical supplied by Tech Serve Solutions

AntibioticsAntibiotics A to ZAntibiotics A-FAntibiotics by ApplicationAntifungalBiochemicals and ReagentsChemical Structure ClassGenetic Marker SelectionGlycopeptidesMechanism of Action

01 /Applications

Tumor Cytotoxicity Studies

Bleomycin sulfate is used in vitro to investigate tumour-specific cytotoxic effects on various human oral cell lines, including normal fibroblasts and oral squamous cell carcinoma cell lines, as well as human promyelocytic leukemia HL-60 cells.

DNA Strand Scission Research

This compound serves as a valuable tool for researchers studying the mechanisms of DNA strand scission and breaking mediated by free radicals.

Genetic Marker Selection

It is recommended as a selection agent in molecular biology for identifying transformed cells, especially in plant genetic engineering, at concentrations of 10-100 μg/ml.

02 /Properties

Grade	for fluorescence
Form	powder
Colour	white
Solubility	H2O: soluble20 mg/mL
Storage temperature	2-8°C
Application	Bleomycin sulfate is used to study tumor-specific cytotoxic activity in certain cell lines such as human normal oral cells(gingival fibrobast HGF, pulp cell HPC and periodontal ligament fibroblast HPLF), human oral squamous cell carcinoma (HSC-2, HSC-3, HSC-4, Ca9-22 and NA) and human promyelocytic leukemia HL-60 cells1. It is used to study free radical-mediated mechanisms of DNA strand scission/breaking and as a transformed cell selection agent, especially for plant transformants. Recommended for use as a selection agent at 10-100 μg/ml.

03 /Safety & handling

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Danger

Hazard statements

H340May cause genetic defects
H351Suspected of causing cancer
H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use
P281Use personal protective equipment as required
P308IF exposed or concerned

Protective equipment	Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	46-63-40
Safety statements (S)	36/37-45
Cation traces	Cu: ≤0.10%

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

9041-93-4

MDL number

MFCD00070310

05 /Additional specifications

Quality	lyophilized

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Bleomycin sulfate used for?

Bleomycin sulfate is used in research to study tumour-specific cytotoxic activity in cell lines, investigate free radical-mediated DNA strand scission mechanisms, and as a selection agent for transformed cells, particularly plant transformants.

What is the CAS number and formula for Bleomycin sulfate?

The CAS number for Bleomycin sulfate is 9041-93-4. The formula is not specified in the provided data.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Bleomycin sulfate in a 'for fluorescence' grade, as a lyophilized white powder. We do not represent this product as USP, BP, or EP grade.

What are the safety and handling precautions for Bleomycin sulfate?

Bleomycin sulfate is classified as a Danger substance (GHS08) with hazard statements H340 (May cause genetic defects), H351 (Suspected of causing cancer), and H361 (Suspected of damaging fertility or the unborn child). Appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection (N100 or P3 filters), is essential during handling. Always follow precautionary statements P201, P281, and P308 + P313.

How is Bleomycin sulfate packed and shipped?

Bleomycin sulfate is supplied as a powder and typically stored at 2-8°C. Tech Serve Solutions, as a global supplier and exporter, can accommodate various shipping and export requirements.

How can I request a sample or quote for Bleomycin sulfate?

To request a sample or a quote for Bleomycin sulfate, please contact our sales team through the website or by phone, providing your specific requirements.