Boc-Asn(Trt)-OH
Boc-Asn(Trt)-OH (CAS: 132388-68-2), with the molecular formula C28H30N2O5 and a molecular weight of 474.55 g/mol, is a protected amino acid derivative. This compound features an Nα-tert-butoxycarbonyl (Boc) protecting group and an Nγ-trityl (Trt) protecting group on the L-asparagine side chain. It is primarily employed in solid-phase peptide synthesis (SPPS) and solution-phase synthesis to facilitate the controlled assembly of peptide sequences.
- IUPAC
- Nα-Boc-Nγ-trityl-L-asparagine
- Synonyms
- Nα-Boc-Nγ-trityl-L-asparagine
Solid-Phase Peptide Synthesis (SPPS)
Boc-Asn(Trt)-OH is a crucial building block in SPPS. The Boc and Trt protecting groups allow for selective deprotection and coupling steps, enabling the incorporation of asparagine into growing peptide chains while preventing unwanted side reactions.
Solution-Phase Peptide Synthesis
This derivative is also utilized in solution-phase peptide synthesis, offering controlled fragment condensation and amino acid coupling for the construction of peptides and peptidomimetics in a homogeneous reaction environment.
Chemical Biology Research
Researchers in chemical biology use Boc-Asn(Trt)-OH for the synthesis of modified peptides and probes. These molecules are instrumental in studying biological processes, protein-protein interactions, and developing novel therapeutic agents.
Organic Synthesis Intermediate
As a versatile protected amino acid, Boc-Asn(Trt)-OH serves as an intermediate in complex organic synthesis pathways, particularly for constructing molecules with specific amide functionalities and chiral centres.
| Molecular weight | 474.55 |
|---|---|
| Empirical formula | C28H30N2O5 |
| Assay | ≥99.0% (TLC) |
| Optical activity | [α]20/D −20±2°, c = 1% in methanol |
| Melting point | ~205 °C (dec.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Boc-Asn(Trt)-OH primarily used for?
+
Boc-Asn(Trt)-OH is primarily used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis, facilitating the controlled incorporation of asparagine into peptide chains.
What are the CAS number and molecular formula for Boc-Asn(Trt)-OH?
+
The CAS number for Boc-Asn(Trt)-OH is 132388-68-2, and its molecular formula is C28H30N2O5.
What grade and purity does Tech Serve Solutions supply for Boc-Asn(Trt)-OH?
+
Tech Serve Solutions supplies Boc-Asn(Trt)-OH with an assay of ≥99.0% determined by TLC. We do not represent this product as USP, BP, or EP grade.
How is Boc-Asn(Trt)-OH handled and stored?
+
Handling Boc-Asn(Trt)-OH requires appropriate personal protective equipment, including eyeshields and gloves, and potentially a type N95 respirator filter. The compound has a melting point of approximately 205 °C (dec.). Store in a cool, dry place according to standard chemical storage practices.
How is Boc-Asn(Trt)-OH packed, shipped, and exported?
+
Boc-Asn(Trt)-OH is carefully packed to ensure stability during transit and is exported globally by Tech Serve Solutions in compliance with all relevant shipping regulations for chemical compounds.
How can I request a sample or quote for Boc-Asn(Trt)-OH?
+
To request a sample or a quote for Boc-Asn(Trt)-OH, please contact our sales department through the TSS website or by direct inquiry, providing your contact details and required quantity.
What is the optical activity of Boc-Asn(Trt)-OH?
+
The optical activity of Boc-Asn(Trt)-OH is [α]20/D −20±2°, measured at a concentration of 1% in methanol.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis