(−)-Blebbistatin
(−)-Blebbistatin (CAS: 856925-71-8, C18H16N2O2) is a selective inhibitor of non-muscle myosin II, essential for cellular processes like cytokinesis and muscle contraction. This small molecule bioactive compound is crucial for research into cell motility, apoptosis, and cell cycle regulation. Its ability to disrupt the actin cytoskeleton makes it an invaluable tool in cell biology laboratories investigating fundamental cellular mechanics and signalling pathways. Tech Serve Solutions supplies this research-grade chemical for scientific inquiry.
- IUPAC
- 1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2.3-b]-7-methylquinolin-4-one
Myosin II Inhibition
(−)-Blebbistatin acts as a potent and specific inhibitor of myosin II ATPase activity. This allows researchers to study the role of myosin II in various cellular functions, including cell division, migration, and contractility.
Cytoskeletal Research
By disrupting the interaction between actin and myosin, blebbistatin provides a valuable tool for investigating the dynamics of the actin cytoskeleton. It is used to probe cellular structural organization and mechanical properties.
Apoptosis and Cell Cycle Studies
Research suggests that myosin II activity is implicated in apoptosis and cell cycle progression. (–)-Blebbistatin can be employed to explore these connections and understand the molecular mechanisms involved.
Cell Motility and Migration
As myosin II is critical for cell shape and movement, blebbistatin is frequently used to study cell migration dynamics, wound healing models, and other processes dependent on cellular motility.
| Molecular weight | 292.33 |
|---|---|
| Empirical formula | C18H16N2O2 |
| Form | solid |
| Solubility | DMSO: soluble5 mg/mLchloroform: soluble(lit.)ethyl acetate: soluble(lit.)methanol: soluble(lit.)methylene chloride: soluble(lit.) |
| Storage temperature | −20°C |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (–)-Blebbistatin used for?
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(–)-Blebbistatin is primarily used as a selective inhibitor of non-muscle myosin II in scientific research. It is employed to study cellular processes such as cytokinesis, cell motility, apoptosis, and the dynamics of the actin cytoskeleton.
What is the CAS number and molecular formula for (–)-Blebbistatin?
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The CAS number for (–)-Blebbistatin is 856925-71-8, and its molecular formula is C18H16N2O2.
What grade and purity does Tech Serve Solutions supply for (–)-Blebbistatin?
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Tech Serve Solutions supplies (–)-Blebbistatin as a research-grade chemical. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should (–)-Blebbistatin be handled safely?
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Handle (–)-Blebbistatin with appropriate personal protective equipment, including a dust mask (N95 US type), eyeshields, face shields, and gloves. Avoid inhalation of dust and contact with skin and eyes. Refer to the Safety Data Sheet for detailed handling instructions.
Is (–)-Blebbistatin a controlled substance?
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The provided data does not indicate that (–)-Blebbistatin is a controlled substance.
How is (–)-Blebbistatin shipped and exported by TSS?
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Tech Serve Solutions, as a global supplier and exporter, ships and exports (–)-Blebbistatin in compliance with all relevant international regulations for chemical transport. Packaging is designed to maintain product integrity during transit.
How can I request a quote or sample of (–)-Blebbistatin?
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To request a quote or sample of (–)-Blebbistatin, please contact our sales department through the website or by phone, providing your specific requirements.
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