(−)-Cotinine
(−)-Cotinine (CAS: 486-56-6), with the molecular formula C10H12N2O and a molecular weight of 176.22 g/mol, is a bioactive small molecule. It is the primary metabolite of nicotine. This compound is utilised in scientific research for its role in cell signaling and neuroscience, particularly in studies involving neurotransmission and ligand-gated ion channels. Tech Serve Solutions supplies this chemical for research and development purposes.
- IUPAC
- (S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone,S(−)-1-Methyl-5-(3-pyridyl)-2-pyrrolidone
- Synonyms
- (S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinoneS(−)-1-Methyl-5-(3-pyridyl)-2-pyrrolidone
Neuroscience Research
(−)-Cotinine serves as a valuable tool in neuroscience research due to its known interactions with nicotinic acetylcholine receptors. It is used to study neurotransmission and the effects of cholinergic compounds.
Metabolism Studies
As the principal metabolite of nicotine, cotinine is frequently employed in pharmacological and toxicological studies to investigate nicotine metabolism in biological systems.
Cell Signaling Investigations
This compound can be used in cell biology to explore cellular signaling pathways, particularly those influenced by cholinergic activity and receptor modulation.
| Molecular weight | 176.22 |
|---|---|
| Empirical formula | C10H12N2O |
| Assay | ≥98% |
| Boiling point | 250 °C/150 mmHg(lit.) |
| Storage temperature | 2-8°C |
| Melting point | 40-42 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... CYP1A2(1544), CYP2A6(1548)mouse ... Cyp2a5(13087) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (–)-Cotinine used for?
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(–)-Cotinine is used in scientific research, primarily in neuroscience and cell biology, to study neurotransmission, cell signaling, and nicotine metabolism. It is a key metabolite of nicotine.
What are the CAS number and formula for (–)-Cotinine?
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The CAS number for (–)-Cotinine is 486-56-6, and its molecular formula is C10H12N2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (–)-Cotinine with an assay of ≥98%. We do not represent this product as USP, BP, or EP grade.
How should (–)-Cotinine be handled safely?
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Handle (–)-Cotinine with appropriate personal protective equipment, including a dust mask (N95 recommended), eyeshields, and gloves. It is classified as harmful if swallowed and causes skin and eye irritation, and may cause respiratory irritation (H302-H315-H319-H335). Ensure good ventilation.
How is (–)-Cotinine packed, shipped, and exported?
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Tech Serve Solutions carefully packs and exports chemicals globally, adhering to all relevant shipping regulations. Specific packaging details are confirmed upon order.
How can I request a quote or sample for (–)-Cotinine?
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To request a quote or sample of (–)-Cotinine, please contact our sales department via the website or by phone.
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