Bis(trimethylsilyl) malonate
Bis(trimethylsilyl) malonate (CAS: 18457-04-0) is an organosilicon compound with the linear formula (CH3)3SiOCOCH2COOSi(CH3)3 and a molecular weight of 248.42 g/mol. It serves as a valuable building block in organic synthesis, particularly as a cyclocondensation agent. This ester is also employed in the preparation of important chemical intermediates like β-keto acids and methyl ketones, offering versatility for chemical research and development.
- IUPAC
- Malonic acid bis(trimethylsilyl ester)
- Synonyms
- Malonic acid bis(trimethylsilyl ester)
Cyclocondensation Agent
Bis(trimethylsilyl) malonate is utilised as a cyclocondensation agent in various organic synthesis reactions. Its structure facilitates the formation of cyclic compounds, making it useful in complex molecular construction.
Synthesis of β-keto acids
This compound is instrumental in the preparation of β-keto acids. These intermediates are crucial in various synthetic pathways within pharmaceutical and fine chemical industries.
Preparation of Methyl Ketones
Bis(trimethylsilyl) malonate finds application in the synthesis of methyl ketones. This is a significant transformation for accessing a range of carbonyl-containing organic molecules.
| Molecular weight | 248.42 |
|---|---|
| Linear formula | (CH3)3SiOCOCH2COOSi(CH3)3 |
| Assay | ≥98.0% (GC) |
| Boiling point | 63-66 °C/1 mmHg(lit.) |
| Density | 0.974 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.416(lit.)n20/D 1.417 |
| Storage temperature | 2-8°C |
| Application | Bis(trimethylsilyl) malonate was used as cyclocondensation agent in cyclocondensation reactions. It was also used in the preparation of β-keto acids and methyl ketones1. |
Hazard statements
- H226Flammable liquid and vapour
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 24 °C / 75.2 °F |
| Transport (UN / ADR) | UN 3272 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F |
| Risk statements (R) | 11 |
| Safety statements (S) | 16 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bis(trimethylsilyl) malonate used for?
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Bis(trimethylsilyl) malonate is used as a cyclocondensation agent and in the preparation of β-keto acids and methyl ketones.
What are the CAS number and formula for Bis(trimethylsilyl) malonate?
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The CAS number for Bis(trimethylsilyl) malonate is 18457-04-0 and its linear formula is (CH3)3SiOCOCH2COOSi(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Bis(trimethylsilyl) malonate with an assay of ≥98.0% (GC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
How should Bis(trimethylsilyl) malonate be handled safely?
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Bis(trimethylsilyl) malonate is a flammable liquid and vapour (H226). Handle with appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, in a well-ventilated area. Store at 2-8°C.
How is Bis(trimethylsilyl) malonate packed, shipped, and exported?
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Bis(trimethylsilyl) malonate is carefully packed according to international shipping regulations for hazardous materials. As a global supplier, Tech Serve Solutions exports this chemical worldwide.
How can I request a sample or quote for Bis(trimethylsilyl) malonate?
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To request a sample or obtain a quote for Bis(trimethylsilyl) malonate, please contact our sales department through the website or call us directly.
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