Bis(tri-tert-butylphosphine)palladium(0)

CAS 53199-31-8C24H54P2PdCatalysis & Inorganic

Bis(tri-tert-butylphosphine)palladium(0) (CAS: 53199-31-8; Formula: C24H54P2Pd) is a palladium complex widely employed as a highly active catalyst in organic synthesis. With a molecular weight of 511.05 g/mol, it is particularly recognised for its efficacy in promoting challenging cross-coupling reactions. Its steric bulk and electron-rich nature facilitate reactions that are difficult with other palladium catalysts, making it invaluable in academic and industrial research for the formation of carbon-carbon and carbon-heteroatom bonds.

IUPAC: Pd(t-Bu3P)2

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Bis(tri-tert-butylphosphine)palladium(0) (C24H54P2Pd) — chemical structure, CAS 53199-31-8; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical SynthesisHomogeneous Pd CatalystsPalladium

01 /Applications

Suzuki Coupling Catalyst

This palladium complex serves as an effective catalyst for Suzuki coupling reactions, notably enabling the coupling of multisubstituted sp³-carbon centres, which can be challenging for less sterically demanding catalysts.

Stille Coupling Reagent

It is utilized as a catalyst in the Stille coupling reaction, demonstrating efficacy in the coupling of aryl chlorides, a class of substrates that often require robust catalytic systems for activation.

Negishi Coupling Facilitator

Bis(tri-tert-butylphosphine)palladium(0) facilitates the Negishi coupling reaction, a valuable method for forming carbon-carbon bonds between organozinc reagents and organic halides or pseudohalides.

Heck Reaction Promoter

The compound acts as a catalyst in the Heck coupling reaction, enabling the synthesis of tetrasubstituted olefins, which are important structural motifs in various organic molecules.

Buchwald-Hartwig Amination Catalyst

It is employed as a catalyst in the Buchwald-Hartwig amination, facilitating the formation of carbon-nitrogen bonds between aryl halides and amines.

Carbonylation Reactions

This palladium complex catalyses the carbonylation of aryl halides when reacted with carbamoylsilanes, providing a route to substituted amides.

02 /Properties

Molecular weight	511.05
Empirical formula	C24H54P2Pd
Storage temperature	−20°C
Application	• Catalyst for Suzuki coupling on a multisubstituted sp3-carbon1 (eq. 1)• Catalyst for Stille coupling reaction of aryl chlorides2 (eq. 2)• Catalyst for Negishi coupling reaction3 (eq. 3)• Catalyst for Heck coupling to form tetrasubstituted olefins4 (eq. 4)• Catalyst for Buchwald-Hartwig amination of aryl halide5 (eq. 5)• Catalyst for carbonylation of aryl halides with carbamoylsilanes6 (eq. 6)t-Bu3P)2 catalyst\" >=\"\">
Melting point	258-272 °C

03 /Identifiers & registry

CAS number

53199-31-8

MDL number

MFCD03094580

PubChem substance

24884857

04 /Additional specifications

Greener Alternative Product Characteristics	Catalysis

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Bis(tri-tert-butylphosphine)palladium(0) primarily used for?

Bis(tri-tert-butylphosphine)palladium(0) is primarily used as a highly effective catalyst in various cross-coupling reactions within organic synthesis, including Suzuki, Stille, Negishi, Heck, and Buchwald-Hartwig aminations.

What are the CAS number and formula for Bis(tri-tert-butylphosphine)palladium(0)?

The CAS number is 53199-31-8 and the empirical formula is C24H54P2Pd.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this compound as a research chemical. The specific assay and purity are detailed in the product's Certificate of Analysis. We do not represent this product as meeting USP, BP, EP, or other pharmacopoeia standards.

What are the safety and handling considerations for Bis(tri-tert-butylphosphine)palladium(0)?

This compound is classified under GHS with a Water Hazard Class of 3 (WGK 3), indicating it is hazardous to aquatic life. Handle with appropriate personal protective equipment in a well-ventilated area. Consult the Safety Data Sheet (SDS) for comprehensive safety information.

How is Bis(tri-tert-butylphosphine)palladium(0) stored and shipped?

The product requires storage at −20°C. As a global supplier and exporter, Tech Serve Solutions ensures compliant packaging and shipping procedures for this chemical.

How can I request a sample or a quote?

To request a sample or a quote for Bis(tri-tert-butylphosphine)palladium(0), please use the 'Request a Quote' or 'Contact Us' form on the Tech Serve Solutions website, specifying the product CAS number 53199-31-8.