Bis(4-methoxyphenyl)chlorophosphine
Bis(4-methoxyphenyl)chlorophosphine (CAS 13685-30-8; C14H14ClO2P; molar mass 280.69 g/mol) is an organophosphorus reagent supplied by Tech Serve Solutions as a low-melting solid (m.p. 62–66 °C) at 95% assay. Bearing a reactive phosphorus–chlorine bond flanked by two electron-rich 4-methoxyphenyl groups, this phosphinous chloride is a moisture-sensitive building block used to install di(4-methoxyphenyl)phosphino units in tertiary phosphines and chiral ligands for asymmetric catalysis.
- IUPAC
- P,P-Bis(4-methoxyphenyl)phosphinous chloride
- Synonyms
- Bis(4-methoxyphenyl)chlorophosphineP,P-Bis(4-methoxyphenyl)phosphinous chlorideChlorobis(4-methoxyphenyl)phosphineBis(4-methoxyphenyl)phosphinous chlorideDi(4-methoxyphenyl)chlorophosphineCAS 13685-30-8
Phosphine ligand synthesis
The electrophilic P–Cl bond reacts readily with carbon and other nucleophiles, making it a convenient reagent for introducing the di(4-methoxyphenyl)phosphino group when constructing tertiary phosphines and chelating bis(phosphine) ligands.
Asymmetric catalysis building block
It serves as a reactant in routes toward ligands for asymmetric transformations, including allylic substitution, hydrogenation, the intermolecular Pauson–Khand reaction of symmetrically substituted alkynes and intramolecular alpha-arylation of aldehydes.
Phosphane-borane chemistry
The compound is used as a reactant in the alcoholysis of phosphane-boranes, supporting the preparation and deprotection of borane-protected phosphorus intermediates.
Hemilabile ligand studies
It is applied in probing the hemilabile coordination sites of bis(phosphine) monoxide ligands, aiding fundamental studies of metal–phosphorus coordination behaviour.
Research and method development
As a defined phosphorus precursor, it is employed in academic and industrial laboratories developing new organophosphorus compounds and catalytic methods.
| Molecular weight | 280.69 |
|---|---|
| Empirical formula | C14H14ClO2P |
| Assay | 95% |
| Application | Reactant for asymmetric:• Allylic substitution1• Intermolecular Pauson-Khand reaction of symmetrically substituted alkynes2• Hydrogenation3• Intramolecular α-arylation of aldehydes4Reactant for:• Alcoholysis of phosphane-boranes5• Probing hemilabile sites of Bis(phosphine) monoxide ligands6 |
| Melting point | 62-66 °C |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bis(4-methoxyphenyl)chlorophosphine used for?
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It is used chiefly as an organophosphorus building block. Its reactive phosphorus–chlorine bond lets chemists install the di(4-methoxyphenyl)phosphino group into tertiary phosphines and chiral ligands used in asymmetric catalysis, and it serves as a reactant in phosphane-borane alcoholysis and related ligand studies.
What is the CAS number and molecular formula of Bis(4-methoxyphenyl)chlorophosphine?
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The CAS number is 13685-30-8 and the empirical formula is C14H14ClO2P (Hill notation), corresponding to a molecular weight of 280.69 g/mol. It is also known as P,P-bis(4-methoxyphenyl)phosphinous chloride.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Bis(4-methoxyphenyl)chlorophosphine at a typical assay of 95% as a research and synthesis-grade reagent. It is a low-melting solid with a melting point of 62–66 °C. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis is provided with each batch.
What are the safety and handling hazards of Bis(4-methoxyphenyl)chlorophosphine?
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It is classified GHS05 with the signal word Danger and hazard statement H314: causes severe skin burns and eye damage. As a phosphinous chloride it is moisture-sensitive and corrosive. Handle under dry, inert conditions with eye/face protection, suitable gloves and appropriate respiratory protection, following the precautionary advice P280, P305+P351+P338 and P310. Refer to the SDS before use.
How is Bis(4-methoxyphenyl)chlorophosphine packed, shipped and exported?
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It is packed in tightly sealed, moisture-excluding containers appropriate to the order quantity and is classified for transport as UN 3261, Class 8, Packing Group II (corrosive). Tech Serve Solutions ships internationally with full export documentation and an SDS, in line with applicable dangerous-goods regulations.
How do I request a sample or a quote?
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Contact Tech Serve Solutions with your required quantity, purity and packaging, and we will respond with availability, lead time and export terms. Sample requests and bulk enquiries for Bis(4-methoxyphenyl)chlorophosphine are welcome from research and manufacturing customers worldwide.
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