Aprindine hydrochloride
Aprindine hydrochloride (CAS: 33237-74-0) is a potent compound with the molecular formula C22H30N2 · HCl and a molecular weight of 358.95. It functions as a class Ib antiarrhythmic agent and a blocker of hERG channels. Additionally, it inhibits calmodulin-stimulated cyclic 3′:5′-nucleotide phosphodiesterase and Ca-ATPase, positioning it as a valuable tool in cardiovascular research and cell signalling studies.
- IUPAC
- N-(2,3-Dihydro-1H-inden-2-yl)-N′,N′-diethyl-N-phenyl-1,3-propanediamine hydrochloride,Amidonal
- Synonyms
- Amidonal
hERG Channel Blocker
Aprindine hydrochloride is recognised for its ability to block hERG channels, which are crucial in cardiac repolarisation. This property makes it a significant compound for research into cardiac ion channel function and related disorders.
Antiarrhythmic Agent Research
As a class Ib antiarrhythmic, Aprindine hydrochloride is studied for its effects on cardiac action potentials. Its application aids in understanding the mechanisms of arrhythmias and the development of potential therapeutic strategies.
Enzyme Inhibition Studies
The compound inhibits calmodulin-stimulated cyclic 3′:5′-nucleotide phosphodiesterase and Ca-ATPase. This enzymatic inhibition activity makes Aprindine hydrochloride useful for researchers investigating cellular energy regulation and signalling pathways.
| Molecular weight | 358.95 |
|---|---|
| Empirical formula | C22H30N2 · HCl |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Solubility | H2O: >10 mg/mL |
| Storage temperature | 2-8°C |
| Application | Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine hydrochloride also inhibits the activities of calmodulin-sitmulated cyclic 3′:5′-nucleotide phosphodiesterase and Ca-ATPase. |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Aprindine hydrochloride used for?
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Aprindine hydrochloride is used as a class Ib antiarrhythmic and hERG channel blocker. It also inhibits calmodulin-stimulated cyclic 3′:5′-nucleotide phosphodiesterase and Ca-ATPase, making it valuable in cardiovascular research and cell signalling studies.
What is the CAS number and formula for Aprindine hydrochloride?
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The CAS number for Aprindine hydrochloride is 33237-74-0, and its molecular formula is C22H30N2 · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Aprindine hydrochloride with an assay of ≥98% (HPLC). We do not represent this product as meeting any pharmacopoeia standards such as USP, BP, or EP unless explicitly stated.
How should Aprindine hydrochloride be handled safely?
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Aprindine hydrochloride is a warning substance. Hazards include H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment including a dust mask (type N95), eyeshields, and gloves. Ensure adequate ventilation.
Is Aprindine hydrochloride a controlled substance?
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The provided data does not indicate that Aprindine hydrochloride is a controlled substance.
How is Aprindine hydrochloride shipped and exported?
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Tech Serve Solutions, a specialist global supplier and exporter, handles the packing, shipping, and exporting of Aprindine hydrochloride. Specific shipping details can be provided upon request.
How can I request a quote or sample for Aprindine hydrochloride?
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To request a quote or sample of Aprindine hydrochloride, please contact our sales team via the website or direct inquiry, referencing the product name and CAS number.
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