Amsacrine hydrochloride
Amsacrine hydrochloride (CAS: 54301-15-4), with the empirical formula C21H19N3O3S · HCl and a molecular weight of 429.92 g/mol, is a red to brown powder. This compound is recognised for its role as an inhibitor, particularly targeting topoisomerase II enzymes. It serves as a valuable tool in biochemical research, specifically within studies concerning apoptosis, cell cycle regulation, DNA repair, and cell signalling.
- IUPAC
- 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride,m-AMSA
- Synonyms
- 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride, m-AMSA
Topoisomerase II Inhibition
Amsacrine hydrochloride acts as a potent inhibitor of topoisomerase II, a crucial enzyme involved in DNA replication and transcription. This makes it an important research chemical for studying DNA topology and related cellular processes.
Apoptosis and Cell Cycle Research
The compound is utilised in investigations into programmed cell death (apoptosis) and the regulation of the cell cycle. Its mechanism of action provides insights into cellular responses to DNA damage and therapeutic interventions.
DNA Repair and Metabolism Studies
Amsacrine hydrochloride is a useful reagent for studying DNA repair pathways and the broader aspects of DNA metabolism. Researchers employ it to understand how cells manage DNA integrity and respond to genotoxic agents.
Biochemical and Cell Biology Tool
As a bioactive small molecule, amsacrine hydrochloride is broadly applied in biochemical research and cell biology. It aids in dissecting complex cellular signalling pathways and understanding the function of enzymes.
| Molecular weight | 429.92 |
|---|---|
| Empirical formula | C21H19N3O3S · HCl |
| Assay | ≥98% (TLC) |
| Form | powder |
| Colour | red to brown |
| Solubility | DMSO: soluble10 mg/mL (with heat and sonication)30% ethanol: soluble4 mg/mL |
| Melting point | 197-199 °C(lit.) |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-36/37/38 |
| Safety statements (S) | 26-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... TOP2A(7153), TOP2B(7155) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Amsacrine hydrochloride used for?
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Amsacrine hydrochloride is used in research for studying apoptosis, cell cycle regulation, DNA repair, DNA metabolism, and as a topoisomerase II inhibitor.
What are the CAS number and formula for Amsacrine hydrochloride?
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The CAS number for Amsacrine hydrochloride is 54301-15-4, and its empirical formula is C21H19N3O3S · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Amsacrine hydrochloride with an assay of ≥98% (TLC). We do not represent this product as USP, BP, or EP grade.
What are the primary safety concerns when handling Amsacrine hydrochloride?
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Amsacrine hydrochloride is classified with GHS06 (Danger) and has hazard statements including H301 (Toxic if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and P2 respirator cartridges, is essential.
How is Amsacrine hydrochloride shipped?
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Amsacrine hydrochloride is shipped according to ADR regulations as UN 2811, Class 6.1, Packing Group III.
How can I request a sample or quote for Amsacrine hydrochloride?
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Please contact our sales team to request a sample or obtain a quote for Amsacrine hydrochloride.
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