α-Amanitin
α-Amanitin (CAS: 23109-05-9, C39H54N10O14S, MW: 918.97) is a highly toxic cyclic peptide primarily found in the death cap mushroom, Amanita phalloides. As a potent inhibitor of RNA polymerase II, it is invaluable in biochemical research for studying transcription processes. Its cytotoxic properties also make it a subject of interest in cancer research and a reference standard in toxicology.
Biochemical Research
Utilised as a potent inhibitor of RNA polymerase II, α-Amanitin is crucial for elucidating the mechanisms of eukaryotic gene transcription and cellular signalling pathways.
Toxicology Studies
Serves as a vital reference standard in toxicological assays and forensic investigations, particularly for identifying and quantifying amatoxin poisoning.
Cancer Research
Its cytotoxic effects are investigated for potential therapeutic applications and for understanding mechanisms of cell death in oncology studies.
| Molecular weight | 918.97 |
|---|---|
| Empirical formula | C39H54N10O14S |
| Assay | ≥95.0% (HPLC) |
| Storage temperature | 2-8°C |
| Biological source | from Amanita phalloides |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H330Fatal if inhaled
- H373May cause damage to organs through prolonged exposure
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
- P302IF ON SKIN
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3462 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/27/28-33 |
| Safety statements (S) | 36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is α-Amanitin primarily used for?
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α-Amanitin is primarily used in biochemical research as a potent inhibitor of RNA polymerase II to study transcription, and in toxicology as a reference standard.
What is the CAS number and molecular formula for α-Amanitin?
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The CAS number for α-Amanitin is 23109-05-9, and its molecular formula is C39H54N10O14S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies α-Amanitin with an assay of ≥95.0% (HPLC). This product is intended for research purposes and is not represented as USP, BP, EP, or pharmacopoeia grade.
How should α-Amanitin be handled safely?
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α-Amanitin is extremely toxic (Danger: H300, H310, H330, H373). Handle with extreme caution in a well-ventilated area or fume hood, wearing appropriate personal protective equipment including eyeshields, gloves, and a suitable respirator.
How is α-Amanitin shipped and exported?
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α-Amanitin is shipped and exported under strict regulations, adhering to UN 3462, Hazard Class 6.1, Packing Group II, due to its high toxicity. International shipping and export compliance is managed by our experienced logistics team.
How can I request a sample or a quote for α-Amanitin?
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To request a sample or a quote for α-Amanitin, please contact our sales department via the website or by telephone, providing your specific requirements.
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