Allyl chloroformate
Allyl chloroformate (CAS: 2937-50-0), with the linear formula ClCOOCH2CH=CH2 and a molecular weight of 120.53 g/mol, is a chemical reagent primarily utilised in organic synthesis. It serves as a versatile agent in amine protection and participates in reactions such as ring-expanding allylation, leading to the formation of cyclic diketones. Its applications span chemical synthesis, peptide chemistry, and chemical biology research.
Amine Protection
Allyl chloroformate is employed as a protecting group for amines in organic synthesis. The resulting allyl carbamates are stable under various conditions and can be selectively removed when required.
Ring-Expanding Allylation
This reagent is utilized in specific allylation reactions, notably leading to the synthesis of 1,4-cycloheptanediones. This transformation is valuable in constructing complex carbocyclic frameworks.
Peptide Chemistry
Within peptide synthesis, allyl chloroformate can be used to protect amino groups. Its unique deprotection conditions offer orthogonality to other common protecting groups.
Chemical Synthesis Reagent
As a synthetic reagent, Allyl chloroformate enables the introduction of the allyloxycarbonyl (Alloc) group, a functional handle used in diverse synthetic strategies and for further chemical modifications.
| Molecular weight | 120.53 |
|---|---|
| Linear formula | ClCOOCH2CH=CH2 |
| Assay | 97% |
| Boiling point | ~27 °C/11 mmHg(lit.) |
| Density | 1.134 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.422(lit.) |
| Vapour pressure | 3.67 psi (20 °C) |
| Storage temperature | −20°C |
| Application | Reagent employed in ring-expanding allylation leading to 1,4-cycloheptanediones.1 |
Hazard statements
- H226Flammable liquid and vapour
- H301Toxic if swallowed
- H314Causes severe skin burns and eye damage
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 31 °C / 87.8 °F |
| Transport (UN / ADR) | UN 1722 8(3)(6.1) |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 10-22-26-34 |
| Safety statements (S) | 26-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Allyl chloroformate used for?
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Allyl chloroformate is used as a reagent in organic synthesis, notably for amine protection and in ring-expanding allylation reactions that yield 1,4-cycloheptanediones. It also finds applications in peptide chemistry and chemical biology.
What are the CAS number and formula for Allyl chloroformate?
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The CAS number for Allyl chloroformate is 2937-50-0, and its linear formula is ClCOOCH2CH=CH2.
What grade and purity does Tech Serve Solutions supply for Allyl chloroformate?
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Tech Serve Solutions supplies Allyl chloroformate with a purity of 97% assay. This product is intended for research and technical use and is not represented as USP, BP, or EP grade.
How should Allyl chloroformate be handled safely?
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Allyl chloroformate is a dangerous substance requiring careful handling. It is highly flammable (flash point 31 °C), toxic if swallowed, causes severe skin burns and eye damage, and is toxic if inhaled. Always use appropriate personal protective equipment, including gloves, goggles, face shields, and a suitable respirator, and handle in a well-ventilated area or fume hood. Refer to the Safety Data Sheet for full details.
How is Allyl chloroformate packed, shipped, and exported?
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Tech Serve Solutions offers Allyl chloroformate for global export, adhering to stringent packaging and shipping regulations for hazardous chemicals. Contact us for specific export details.
How can I request a quote or sample for Allyl chloroformate?
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To request a quote or a sample of Allyl chloroformate, please contact our sales team through the website or by phone. We will respond promptly to your inquiry.
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