Agomelatine

CAS 138112-76-2C15H17NO2Biochemicals & Reagents

Agomelatine (CAS: 138112-76-2), with the molecular formula C15H17NO2 and a molecular weight of 243.30 g/mol, is a key compound in neuroscientific research. It functions as a potent agonist for melatonin receptors MT1 and MT2 and also exhibits antagonist activity at serotonin 5-HT2C receptors. This unique pharmacological profile makes it a valuable tool for studying circadian rhythm disorders and mood regulation.

IUPAC: N-[2-(7-Methoxy-1-naphthalenyl)ethyl]-acetamide,S-20098
Synonyms: N-[2-(7-Methoxy-1-naphthalenyl)ethyl]-acetamideS-20098

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Agomelatine (C15H17NO2) — chemical structure, CAS 138112-76-2; Life Science, fine chemical supplied by Tech Serve Solutions

A-AMBioactive Small MoleculesBiochemicals and ReagentsCell BiologyGPCR ModulatorsGPCR ProteinsModulators and AntibodiesMeatonin - Receptor AgonistsMelatoninsNeurobiology

01 /Applications

Neuroscience Research

Agomelatine is widely used in preclinical research to investigate the mechanisms underlying mood disorders, anxiety, and sleep disturbances. Its selective action on melatonin and serotonin receptors makes it a critical probe for understanding neural pathways involved in these conditions.

Drug Discovery and Development

As an approved therapeutic agent in some regions, Agomelatine serves as a reference compound and a lead structure in the development of novel treatments for depression and other neurological conditions. Its known efficacy and safety profile inform ongoing drug discovery efforts.

Melatonin Receptor Studies

This compound is instrumental in characterizing the function and signaling of MT1 and MT2 melatonin receptors. Researchers utilize Agomelatine to explore the physiological roles of these receptors in sleep-wake cycles, seasonal affective disorder, and other chronobiological processes.

02 /Properties

Molecular weight	243.30
Empirical formula	C15H17NO2
Assay	≥98% (HPLC)
Form	powder
Colour	white to off-white
Solubility	DMSO: >50 mg/mL
Storage temperature	2-8°C

03 /Safety & handling

GHS hazard pictogram: Environmental hazard (GHS09) — Environmental hazard

Warning

Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment

Transport (UN / ADR)	UN 3077 9 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	N
Risk statements (R)	50
Safety statements (S)	61

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

138112-76-2

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Agomelatine used for?

Agomelatine is used in scientific research to study neurobiology, particularly concerning mood disorders, sleep regulation, and the function of melatonin and serotonin receptors. It is also a reference compound in drug discovery for neurological conditions.

What is the CAS number and chemical formula for Agomelatine?

The CAS number for Agomelatine is 138112-76-2, and its chemical formula is C15H17NO2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Agomelatine with a purity of ≥98% as determined by HPLC. We do not represent this product as USP, BP, EP, or any other pharmacopoeial grade.

How should Agomelatine be handled and stored?

Agomelatine is classified as hazardous to the aquatic environment (H400). Handle with care to avoid release into the environment. Store at 2-8°C.

Is Agomelatine a controlled substance?

The provided data does not indicate that Agomelatine is a controlled substance. However, users should always verify local regulations.

How can I request a quote or sample for Agomelatine?

Please contact our sales department via the website or by phone to request a quote or a sample of Agomelatine.

How is Agomelatine packed and shipped?

Agomelatine is typically supplied as a white to off-white powder. Shipping and export are handled in compliance with relevant regulations, including UN 3077 for transport.