6-Mercapto-1-hexanol
6-Mercapto-1-hexanol (CAS: 1633-78-9), with the linear formula HS(CH2)6OH and a molecular weight of 134.24 g/mol, is a bifunctional organic compound featuring both a thiol and a hydroxyl group. This chemical is primarily utilised in the synthesis of self-assembled monolayers (SAMs), particularly hydrophilic ones, on surfaces like gold. The terminal alcohol group allows for further chemical functionalisation after SAM formation.
- IUPAC
- 6-Hydroxy-1-hexanethiol,6-MCH,6-Mercaptohexan-1-ol,6-Mercaptohexanol,MCH

Self-Assembled Monolayers (SAMs)
This compound is used to create hydrophilic SAMs on gold surfaces and nanoclusters. The terminal hydroxyl group provides a reactive site for subsequent functionalisation with various chemical moieties.
Surface Chemistry Modification
As a building block, 6-Mercapto-1-hexanol enables the modification of material surfaces. Its dual functionality allows for anchoring to substrates via the thiol group while presenting a hydroxyl group for further reactions or to impart specific surface properties.
Organic Synthesis
This molecule serves as a versatile intermediate in organic synthesis, particularly in reactions requiring a thiol and an alcohol functionality within the same molecule for creating complex organic structures or functional materials.
| Molecular weight | 134.24 |
|---|---|
| Linear formula | HS(CH2)6OH |
| Assay | 97% |
| Form | liquid |
| Boiling point | 225 °C(lit.) |
| Density | 0.981 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.486(lit.) |
| Application | This compound is used to produce hydrophilic SAMs. The resulting monolayers which are terminated with alcohols can be further functionalized1 with various groups even when attached to gold nanoclusters.2 |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Flash point | >110 °C / >230 °F |
|---|---|
| Transport (UN / ADR) | UN 3334 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Mercapto-1-hexanol primarily used for?
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6-Mercapto-1-hexanol is primarily used for the production of hydrophilic self-assembled monolayers (SAMs), particularly on gold surfaces and nanoclusters, due to its terminal alcohol group that allows for further functionalisation.
What is the CAS number and chemical formula for 6-Mercapto-1-hexanol?
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The CAS number for 6-Mercapto-1-hexanol is 1633-78-9, and its chemical formula is HS(CH2)6OH.
What grade and purity does Tech Serve Solutions supply for 6-Mercapto-1-hexanol?
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Tech Serve Solutions supplies 6-Mercapto-1-hexanol with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should 6-Mercapto-1-hexanol be handled safely?
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6-Mercapto-1-hexanol is a Warning substance, with hazards including skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, ensuring good ventilation. Avoid breathing vapours and contact with skin and eyes. Refer to the Safety Data Sheet for detailed handling instructions.
Is 6-Mercapto-1-hexanol available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 6-Mercapto-1-hexanol.
How can I request a sample or quote for 6-Mercapto-1-hexanol?
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To request a sample or a quote for 6-Mercapto-1-hexanol, please contact our sales team via the website or by phone.
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