5-(p-Methylphenyl)-5-phenylhydantoin
5-(p-Methylphenyl)-5-phenylhydantoin (CAS 51169-17-6, C16H14N2O2) is a hydantoin derivative with a molecular weight of 266.29 g/mol. This compound serves as a valuable building block in chemical synthesis, particularly within the realm of heterocyclic chemistry. Its primary applications include use as an internal standard in analytical methods such as GC-MS for the quantification of pharmaceuticals and in assessing the chromatographic properties of stationary phases for toxicological screening.
- IUPAC
- 5-(4-Methylphenyl)-,5-phenylimidazolidine-2,4-dione,5-Phenyl-5-(p-tolyl)hydantoin,MPPH,NSC 32105
- Synonyms
- 5-Phenyl-5-(p-tolyl)hydantoinMPPHNSC 321055-(4-Methylphenyl)-,5-phenylimidazolidine-2,4-dione
Analytical Standard
Utilised as an internal standard in gas chromatography-mass spectrometry (GC-MS) for the precise quantitative determination of drugs in biological samples like saliva and blood. This ensures accurate measurement and reliable data in clinical and forensic toxicology.
Chromatographic Analysis
Employed in the DMD-test to evaluate the chromatographic characteristics of C8- or C18-bonded phases. This application aids in understanding and optimising separation conditions for complex mixtures in pharmaceutical and toxicological analyses.
Chemical Synthesis
Serves as a versatile building block in the synthesis of more complex organic molecules. Its heterocyclic structure makes it a key intermediate for developing novel compounds with potential pharmaceutical or material science applications.
| Molecular weight | 266.29 |
|---|---|
| Empirical formula | C16H14N2O2 |
| Assay | ≥99% |
| Solubility | : soluble50 mg/mL, clear to slightly hazy, colorless to light yellow (DMF:HCl(2:1)) |
| Application | 5-(p-Methylphenyl)-5-phenylhydantoin was used as internal standard in quantitative determination of phenytoin in brain microdialysate, saliva and blood from human samples by GC-MS method . It was used in DMD-test to determine chromatographic properties of C8- or C18-bonded phases for clinical and forensic toxicological screening. |
| Melting point | 225-226 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H351Suspected of causing cancer
- H361Suspected of damaging fertility or the unborn child
Precautionary statements
- P281Use personal protective equipment as required
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 63-22-40 |
| Safety statements (S) | 36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-(p-Methylphenyl)-5-phenylhydantoin used for?
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5-(p-Methylphenyl)-5-phenylhydantoin is primarily used as an internal standard in quantitative analytical methods like GC-MS, and in assessing chromatographic properties for toxicological screening. It also functions as a building block in chemical synthesis.
What are the CAS number and chemical formula for 5-(p-Methylphenyl)-5-phenylhydantoin?
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The CAS number is 51169-17-6 and the empirical formula is C16H14N2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-(p-Methylphenyl)-5-phenylhydantoin with an assay of ≥99%. This product is intended for research and laboratory use; TSS does not represent it as USP, BP, EP or other pharmacopoeial grades.
What are the safety considerations when handling 5-(p-Methylphenyl)-5-phenylhydantoin?
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This compound is classified as harmful if swallowed (H302), suspected of causing cancer (H351), and suspected of damaging fertility or the unborn child (H361). Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (e.g., N100 or P3 filters), is essential. Handle with care in a well-ventilated area.
How is 5-(p-Methylphenyl)-5-phenylhydantoin packed, shipped, and exported?
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This chemical is carefully packed according to international standards for safe transport. Tech Serve Solutions is an experienced global supplier and exporter, ensuring compliance with all relevant shipping regulations for hazardous materials.
How can I request a sample or quote for 5-(p-Methylphenyl)-5-phenylhydantoin?
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Please contact our sales team via the website or direct email, providing your contact details and the quantity required. We will promptly respond with a quotation or sample availability.
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