5′-O-(4,4′-Dimethoxytrityl)thymidine
5′-O-(4,4′-Dimethoxytrityl)thymidine (CAS: 40615-39-2) is a protected nucleoside with the molecular formula C31H32N2O7. This compound serves as a crucial building block in chemical synthesis, particularly for creating modified oligonucleotides and DNA analogues. Its dimethoxytrityl (DMT) protecting group facilitates controlled coupling reactions in solid-phase synthesis, making it valuable in research and development for nucleic acid chemistry.
- IUPAC
- DMT-T
- Synonyms
- DMT-T5'-O-Dimethoxytritylthymidine
Oligonucleotide Synthesis
Utilised as a key phosphoramidite precursor for the automated synthesis of DNA and RNA strands. The DMT group allows for stepwise addition of nucleotide units.
Nucleoside Modification
Enables the introduction of modified thymidine units into nucleic acid sequences for research purposes, such as developing therapeutic oligonucleotides or molecular probes.
Medicinal Chemistry Research
Serves as an intermediate in the synthesis of novel nucleoside derivatives with potential pharmaceutical applications.
Biotechnology Applications
A fundamental reagent in the field of synthetic biology and genetic engineering for constructing custom nucleic acid structures.
| Molecular weight | 544.59 |
|---|---|
| Empirical formula | C31H32N2O7 |
| Assay | 98% |
| Storage temperature | 2-8°C |
| Melting point | 114-116 °C (subl.)(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5′-O-(4,4′-Dimethoxytrityl)thymidine used for?
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It is primarily used as a protected nucleoside building block in the synthesis of oligonucleotides and modified nucleic acids for research in chemistry, biotechnology, and medicinal chemistry.
What is the CAS number and formula for 5′-O-(4,4′-Dimethoxytrityl)thymidine?
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The CAS number is 40615-39-2, and the empirical formula is C31H32N2O7.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5′-O-(4,4′-Dimethoxytrityl)thymidine with an assay of 98%. This product is supplied for laboratory and research purposes and is not represented as USP, BP, EP, or pharmacopoeia grade.
What are the main safety hazards associated with this chemical?
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This compound is a GHS07 irritant, classified with signal word 'Warning'. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used during handling.
How is 5′-O-(4,4′-Dimethoxytrityl)thymidine stored and shipped?
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It should be stored at 2-8°C. As a specialist global supplier, Tech Serve Solutions exports fine chemicals and reagents worldwide, adhering to all necessary shipping regulations.
How can I request a sample or quote for 5′-O-(4,4′-Dimethoxytrityl)thymidine?
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Please contact our sales team via the website or telephone to request a sample or a detailed quotation for your specific requirements.
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