5-Methylthiophene-2-sulfonyl chloride
5-Methylthiophene-2-sulfonyl chloride (CAS: 55854-45-0; Formula: C5H5ClO2S2) is a vital heterocyclic building block essential for chemical synthesis. With a molecular weight of 196.68 g/mol, this organosulfur compound serves as a reactive intermediate in the development of complex organic molecules. Its utility spans various research and development applications, particularly where thiophene derivatives are required.

Organic Synthesis Intermediate
This sulfonyl chloride is employed as a key intermediate in the synthesis of diverse organic compounds. Its reactive sulfonyl chloride group readily participates in nucleophilic substitution reactions, enabling the introduction of the 5-methylthiophene-2-sulfonyl moiety into target molecules.
Pharmaceutical Research
As a thiophene derivative, 5-methylthiophene-2-sulfonyl chloride can be utilized in the exploration of novel pharmaceutical agents. Thiophene rings are present in numerous biologically active compounds, making this reagent valuable for medicinal chemistry programmes.
Materials Science
The compound may find application in the development of functional materials. Thiophene-based structures are known for their electronic and optical properties, suggesting potential uses in organic electronics or polymer science.
| Molecular weight | 196.68 |
|---|---|
| Empirical formula | C5H5ClO2S2 |
| Assay | 97% |
| Density | 1.432 g/mL at 25 °C |
| Refractive index | n20/D 1.569 |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | >110 °C / >230 °F |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Methylthiophene-2-sulfonyl chloride used for?
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5-Methylthiophene-2-sulfonyl chloride is primarily used as a building block and intermediate in organic synthesis, particularly in pharmaceutical research and potentially in materials science, owing to its thiophene structure and reactive sulfonyl chloride group.
What is the CAS number and formula for 5-Methylthiophene-2-sulfonyl chloride?
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The CAS number is 55854-45-0 and the empirical formula is C5H5ClO2S2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Methylthiophene-2-sulfonyl chloride with an assay of 97%. This is a technical/research grade material, and TSS does not represent it as USP, BP, or EP grade.
How should 5-Methylthiophene-2-sulfonyl chloride be handled?
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This compound is classified as Danger, indicated by GHS05 symbol, and carries hazard statement H314 (Causes severe skin burns and eye damage). Handle with extreme caution, wearing appropriate personal protective equipment including gloves, eye protection, and protective clothing. Ensure adequate ventilation. Refer to the Safety Data Sheet for comprehensive handling information.
Is 5-Methylthiophene-2-sulfonyl chloride shipped internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 5-Methylthiophene-2-sulfonyl chloride, and can facilitate international shipments.
How can I request a quote or sample?
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To request a quote or a sample of 5-Methylthiophene-2-sulfonyl chloride, please contact the TSS sales team through our website or designated contact channels.
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