5-Methylthiophene-2-boronic acid pinacol ester

CAS 476004-80-5C11H17BO2SChemical Synthesis

5-Methylthiophene-2-boronic acid pinacol ester (CAS: 476004-80-5; Formula: C11H17BO2S) is a boronate ester derivative crucial in organic synthesis. Possessing a molecular weight of 224.13 g/mol, this compound serves as a versatile building block. It is primarily employed in cross-coupling reactions, particularly Suzuki-Miyaura couplings, to introduce the 5-methylthiophene moiety into complex molecular structures for pharmaceutical and materials science research.

IUPAC: 5-(2-Methylthiophene)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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5-Methylthiophene-2-boronic acid pinacol ester (C11H17BO2S) — chemical structure, CAS 476004-80-5; Chemistry, fine chemical supplied by Tech Serve Solutions

Boronate EstersChemical SynthesisHeteroaryl Boronate EstersOrganometallic Reagents

01 /Applications

Suzuki-Miyaura Cross-Coupling Reactions

Utilised as a coupling partner in Suzuki-Miyaura reactions to form new carbon-carbon bonds, enabling the synthesis of biaryl and heteroaryl compounds.

Organic Synthesis Intermediate

Serves as a key intermediate in the construction of complex organic molecules, including those with potential pharmaceutical activity, by functionalising thiophene rings.

Materials Science

Can be incorporated into the synthesis of novel organic electronic materials, polymers, or dyes where the thiophene core imparts desirable electronic or optical properties.

02 /Properties

Molecular weight	224.13
Empirical formula	C11H17BO2S
Assay	95%
Density	0.937 g/mL at 25 °C(lit.)
Impurities tested	4-5% pinacol

03 /Safety & handling

Flash point	105 °C / 221 °F
Water hazard class (WGK, DE)	2

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

476004-80-5

MDL number

MFCD05664108

PubChem substance

24884082

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 5-Methylthiophene-2-boronic acid pinacol ester used for?

This compound is primarily used as a building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, to introduce the 5-methylthiophene group into larger molecules for pharmaceutical research and materials science.

What are the CAS number and chemical formula for 5-Methylthiophene-2-boronic acid pinacol ester?

The CAS number is 476004-80-5 and the chemical formula is C11H17BO2S.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this chemical with an assay of 95%. Impurities may include up to 4-5% pinacol. This product is not supplied as USP, BP, EP or other pharmacopoeia grade.

What are the safety and handling precautions for this chemical?

This compound has a flash point of 105 °C (221 °F) and is classified under WGK 2 in Germany, indicating it is hazardous to water. Handle with appropriate personal protective equipment in a well-ventilated area.

How is 5-Methylthiophene-2-boronic acid pinacol ester packed and shipped?

Products are carefully packed according to international regulations for shipping and export. Specific packaging details can be provided upon request.