5-Methyl-2-pyridylzinc bromide solution
5-Methyl-2-pyridylzinc bromide solution (CAS: 257876-05-4) is an organozinc reagent with a molecular weight of 237.41 g/mol. Supplied as a 0.5 M solution in THF, it is primarily utilised in chemical synthesis for introducing the 5-methyl-2-pyridyl moiety into organic molecules. Its applications span the development of complex organic structures, particularly in pharmaceutical and agrochemical research, owing to the presence of the pyridine ring which is a common scaffold in bioactive compounds.
Cross-Coupling Reactions
This organozinc reagent serves as a valuable nucleophilic coupling partner in transition metal-catalysed cross-coupling reactions, enabling the formation of new carbon-carbon bonds.
Heterocyclic Synthesis
It is employed in the synthesis of complex heterocyclic compounds, where the 5-methyl-2-pyridyl group can be incorporated into larger molecular frameworks.
Pharmaceutical Intermediate
The reagent is used in the development pathways for pharmaceutical intermediates, leveraging the pyridine structure's prevalence in drug discovery.
Reagent for Organometallic Chemistry
As an organozinc halide, it is a key component in organometallic chemistry, facilitating reactions that might be challenging with other organometallic species.
| Molecular weight | 237.41 |
|---|---|
| Empirical formula | C6H6BrNZn |
| Density | 0.959 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 3399 4.3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-19-37-41 |
| Safety statements (S) | 16-26-39 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Methyl-2-pyridylzinc bromide solution used for?
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5-Methyl-2-pyridylzinc bromide solution is used in chemical synthesis, particularly for cross-coupling reactions and the formation of complex heterocyclic compounds, serving as an intermediate in pharmaceutical and agrochemical research.
What are the CAS number and formula for 5-Methyl-2-pyridylzinc bromide solution?
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The CAS number is 257876-05-4, and the empirical formula is C6H6BrNZn.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in THF. TSS does not represent this product as USP/BP/EP or any pharmacopoeia grade; it is suitable for research and chemical synthesis applications.
How should 5-Methyl-2-pyridylzinc bromide solution be handled?
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This product is flammable and can cause serious eye damage and skin irritation. It may also form explosive peroxides. Handle with extreme care in a well-ventilated area, away from ignition sources. Always wear appropriate personal protective equipment, including eye protection and gloves.
Is 5-Methyl-2-pyridylzinc bromide solution shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and reagents.
How can I request a sample or quote for 5-Methyl-2-pyridylzinc bromide solution?
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Please contact our sales team directly via phone or email to request a sample or a formal quotation for this product.
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