5-Bromo-2-fluorotoluene
5-Bromo-2-fluorotoluene (CAS: 51437-00-4), with the chemical formula CH3C6H3(Br)F and a molecular weight of 189.02 g/mol, is a halogenated aromatic compound. This versatile building block is primarily used in organic synthesis, contributing to the creation of more complex molecules. Its specific substitution pattern makes it valuable in the development of various chemical intermediates and research compounds.
Synthesis of Benzyl Bromide Derivatives
5-Bromo-2-fluorotoluene can be converted to 5-bromo-2-fluorobenzyl bromide via NBS bromination. This derivative is a key intermediate in the synthesis of crown bromofluorobenzene.
Pharmaceutical Intermediate Development
This compound serves as a precursor in the synthesis of bioactive molecules. An example includes its use in creating 3-(4-fluoro-3-methylphenyl)acrylamide, a structure potentially relevant in pharmaceutical research.
Organic Synthesis Building Block
As a fluorinated and brominated toluene derivative, it functions as a valuable building block in general organic synthesis, enabling the introduction of specific functional groups into target molecules.
| Molecular weight | 189.02 |
|---|---|
| Linear formula | CH3C6H3(Br)F |
| Assay | 97% |
| Density | 1.486 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.529(lit.) |
| Application | 5-Bromo-2-fluorotoluene has been used in the preparation of:• 5-bromo-2-fluorobenzyl bromide via N-bromosuccinimide (NBS) bromination, required for the synthesis of crown bromofluorobenzene1• 3-(4-fuoro-3-methylphenyl)acrylamide2 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 73 °C / 163.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Bromo-2-fluorotoluene used for?
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5-Bromo-2-fluorotoluene is used as a building block in organic synthesis, notably in the preparation of intermediates like 5-bromo-2-fluorobenzyl bromide and compounds such as 3-(4-fluoro-3-methylphenyl)acrylamide.
What are the CAS number and formula for 5-Bromo-2-fluorotoluene?
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The CAS number is 51437-00-4 and the linear formula is CH3C6H3(Br)F.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Bromo-2-fluorotoluene with a minimum assay of 97%. This product is intended for research and chemical synthesis purposes and is not supplied as USP, BP, EP, or pharmaceutical grade.
How should 5-Bromo-2-fluorotoluene be handled safely?
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5-Bromo-2-fluorotoluene is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Always use appropriate personal protective equipment, including eyeshields and gloves, and ensure adequate ventilation. Refer to the Safety Data Sheet for detailed handling instructions.
Is 5-Bromo-2-fluorotoluene a controlled substance?
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Based on the provided data, 5-Bromo-2-fluorotoluene is not listed as a controlled substance. However, users should always verify the regulatory status in their specific jurisdiction.
How is 5-Bromo-2-fluorotoluene packed and exported?
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Tech Serve Solutions securely packs and exports fine chemicals like 5-Bromo-2-fluorotoluene in compliance with international shipping regulations for hazardous materials.
How can I request a quote or sample of 5-Bromo-2-fluorotoluene?
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To request a quote or a sample of 5-Bromo-2-fluorotoluene, please contact our sales team through the website or by phone, providing your details and the quantity required.
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