5-Bromo-2-fluorophenylboronic acid
5-Bromo-2-fluorophenylboronic acid (CAS: 112204-57-6), with the molecular formula BrC₆H₃(F)B(OH)₂, is a disubstituted aryl boronic acid. This organometallic reagent is a valuable building block in organic synthesis, particularly in cross-coupling reactions. Its unique structure, featuring both bromine and fluorine substituents on the phenyl ring, allows for diverse synthetic transformations, making it a key intermediate in the development of pharmaceuticals and advanced materials.
- IUPAC
- 5-Bromo-2-fluorobenzeneboronic acid
- Synonyms
- 5-Bromo-2-fluorobenzeneboronic acid
Suzuki-Miyaura Cross-Coupling Reactions
This compound serves as a crucial coupling partner in Suzuki-Miyaura reactions. It facilitates the formation of carbon-carbon bonds, enabling the synthesis of complex biaryl structures and substituted aromatic compounds essential in medicinal chemistry.
Pharmaceutical Intermediate Synthesis
5-Bromo-2-fluorophenylboronic acid is employed in the multi-step synthesis of active pharmaceutical ingredients (APIs). Its functional groups allow for regioselective modifications, contributing to the development of novel therapeutic agents.
Materials Science Research
The compound finds application in the creation of novel organic materials. Its incorporation into polymer backbones or small molecules can tune electronic and optical properties for applications in areas like organic electronics.
| Molecular weight | 218.82 |
|---|---|
| Linear formula | BrC6H3(F)B(OH)2 |
| Melting point | 144-149 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Bromo-2-fluorophenylboronic acid used for?
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5-Bromo-2-fluorophenylboronic acid is primarily used as a building block in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions, and as an intermediate in the synthesis of pharmaceuticals and advanced materials.
What is the CAS number and chemical formula?
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The CAS number for 5-Bromo-2-fluorophenylboronic acid is 112204-57-6, and its chemical formula is BrC₆H₃(F)B(OH)₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Bromo-2-fluorophenylboronic acid with a purity of 97%. We do not represent this product as USP, BP, or EP grade.
How should 5-Bromo-2-fluorophenylboronic acid be handled?
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Handle with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Avoid contact with skin and eyes, and ensure adequate ventilation. Refer to the Safety Data Sheet for detailed information.
Is 5-Bromo-2-fluorophenylboronic acid a controlled substance?
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The provided data does not indicate that 5-Bromo-2-fluorophenylboronic acid is a controlled substance.
How is this chemical shipped?
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Tech Serve Solutions exports fine chemicals globally, adhering to all relevant shipping and handling regulations. Please contact us for specific shipping details regarding your location.
How can I request a quote or sample?
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To request a quote or sample of 5-Bromo-2-fluorophenylboronic acid, please use the 'Request Quote' or 'Request Sample' buttons on our product page or contact our sales team directly.
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