4-(Trifluoromethoxy)phenol
4-(Trifluoromethoxy)phenol (CAS: 828-27-3) is an organic compound with the formula CF3OC6H4OH and a molecular weight of 178.11 g/mol. This phenol derivative, featuring a trifluoromethoxy group, serves as a valuable building block in organic synthesis. It is commonly utilised in the development of pharmaceuticals, agrochemicals, and advanced materials where precise functionalisation is required. Its chemical properties make it an important intermediate for creating complex molecular architectures.
Pharmaceutical Intermediate
Used in the synthesis of active pharmaceutical ingredients (APIs) and advanced drug candidates. Its unique trifluoromethoxy group can influence lipophilicity and metabolic stability in drug molecules.
Agrochemical Development
Serves as a key intermediate for the creation of novel pesticides, herbicides, and fungicides. The trifluoromethoxy moiety can enhance the biological activity and environmental profile of agrochemical products.
Materials Science
Incorporated into the synthesis of specialised polymers and functional materials. The trifluoromethoxy group can impart desirable properties such as thermal stability and specific electronic characteristics.
Research and Development
A versatile reagent for academic and industrial research laboratories exploring new chemical entities and reaction pathways. Enables the introduction of the trifluoromethoxyphenyl group into diverse organic structures.
| Molecular weight | 178.11 |
|---|---|
| Linear formula | CF3OC6H4OH |
| Assay | 98% |
| Boiling point | 92 °C/25 mmHg(lit.) |
| Density | 1.375 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.447(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 86 °C / 186.8 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-27-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Trifluoromethoxy)phenol used for?
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4-(Trifluoromethoxy)phenol is primarily used as a building block in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and advanced materials. It is also a valuable reagent for research and development purposes.
What are the CAS number and chemical formula for 4-(Trifluoromethoxy)phenol?
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The CAS number for 4-(Trifluoromethoxy)phenol is 828-27-3, and its chemical formula is CF3OC6H4OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Trifluoromethoxy)phenol with a purity of 98% (assay). This product is intended for research and chemical synthesis and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 4-(Trifluoromethoxy)phenol be handled safely?
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Based on GHS classifications, 4-(Trifluoromethoxy)phenol is a warning substance, harmful if swallowed, in contact with skin, or inhaled, and causes skin and serious eye irritation. Handling requires appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (e.g., type ABEK respirator filter). Ensure good ventilation and avoid dust formation. Always consult the Safety Data Sheet (SDS) before use.
Is 4-(Trifluoromethoxy)phenol a controlled substance?
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The provided data does not indicate that 4-(Trifluoromethoxy)phenol is a controlled substance.
How is 4-(Trifluoromethoxy)phenol shipped and exported?
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4-(Trifluoromethoxy)phenol is classified under NA 1993 / PGIII for transport. Tech Serve Solutions is a specialist global supplier and exporter, adhering to all relevant shipping and export regulations for chemical products.
How can I request a quote or sample for 4-(Trifluoromethoxy)phenol?
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To request a quote or sample for 4-(Trifluoromethoxy)phenol, please contact our sales department through the website or by phone, providing your specific requirements and shipping details.
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