4-Propoxyphenylboronic acid
4-Propoxyphenylboronic acid (CAS: 186497-67-6; Formula: C11H17BO3; Molar Mass: 208.06 g/mol) is a valuable aryl boronic acid derivative. It serves as a key building block in organic synthesis, particularly in cross-coupling reactions. Its applications span the development of novel pharmaceutical candidates, agrochemicals, and advanced materials, offering researchers a reliable reagent for constructing complex molecular architectures.
Synthesis of Anti-Platelet Agents
Used as a reactant in the synthesis of obovatol derivatives, which have demonstrated anti-platelet activity. This highlights its role in medicinal chemistry research.
Suzuki-Miyaura Coupling Reactions
Employed in Suzuki-Miyaura coupling with chloro arenes, often utilising palladium catalysts. This is a fundamental transformation for C-C bond formation in organic synthesis.
Development of PPARδ Agonists
Key intermediate in the preparation of bisaryl substituted thiazoles and oxazoles. These compounds are investigated for their potential as selective peroxisome proliferator-activated receptor delta (PPARδ) agonists.
Preparation of BACE1 Inhibitors
Facilitates the regioselective Suzuki coupling required for the preparation of selective BACE1 inhibitors, contributing to research in neurological disorders.
Dye Synthesis
Utilised in the preparation of dichroic fluorescent benzothiadiazole dyes, showcasing its utility in materials science and the development of novel optical materials.
| Molecular weight | 180.01 |
|---|---|
| Linear formula | C6H4(OCH2CH2CH3)B(OH)2 |
| Application | Reactant for:• Synthesis of obovatol derivatives as anti-platelet activity1• Suzuki-Miyaura reaction with chloro arenes using (phenylphosphine)palladium catalyst2• Preparation of bisaryl substituted thiazoles and oxazoles as selective peroxisome proliferator-activated receptor δ (PPARδ) agonists3• Selective BACE1 inhibitors using regioselective Suzuki coupling4• Preparation of dichroic fluorescent benzothiadiazole dyes5 |
| Melting point | 123-126 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Propoxyphenylboronic acid used for?
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4-Propoxyphenylboronic acid is primarily used as a reactant in various organic syntheses, including the Suzuki-Miyaura coupling reaction, for the preparation of pharmaceutical intermediates, PPARδ agonists, BACE1 inhibitors, and fluorescent dyes.
What is the CAS number and formula for 4-Propoxyphenylboronic acid?
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The CAS number for 4-Propoxyphenylboronic acid is 186497-67-6, and its linear formula is C11H17BO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a research or technical grade chemical. We do not represent it as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product specifications. Please refer to the product specification sheet for assay details.
What are the safety and handling precautions for 4-Propoxyphenylboronic acid?
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When handling 4-Propoxyphenylboronic acid, it is essential to wear appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. The compound has a WGK Germany rating of 3, indicating a high degree of hazard to water.
How is 4-Propoxyphenylboronic acid packaged and shipped?
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As a global supplier, Tech Serve Solutions exports and ships chemicals worldwide. Packaging is carefully managed to ensure product integrity and compliance with international shipping regulations. Specific packaging details can be provided upon request.
How can I request a sample or quote for 4-Propoxyphenylboronic acid?
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To request a sample or a quotation for 4-Propoxyphenylboronic acid, please contact our sales team through the website or by calling our direct line. Please specify the quantity required and your shipping destination.
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