4-Methylbenzylsulfonyl chloride
4-Methylbenzylsulfonyl chloride (CAS: 51419-59-1), with the linear formula H3CC6H4CH2SO2Cl and a molecular weight of 204.67 g/mol, is a key organic building block. This sulfonyl halide is a useful intermediate in chemical synthesis, particularly for introducing the 4-methylbenzylsulfonyl group into various organic molecules. It is often employed in the preparation of more complex compounds within research and development settings.
- IUPAC
- (4-Methylphenyl)methanesulfonyl chloride,4-Methylbenzenemethanesulfonyl chloride,p-Methyl-α-toluenesulfonyl chloride,p-Tolylmethanesulfonyl chloride
- Synonyms
- (4-Methylphenyl)methanesulfonyl chloride4-Methylbenzenemethanesulfonyl chloridep-Methyl-α-toluenesulfonyl chloridep-Tolylmethanesulfonyl chloride

Chemical Synthesis Intermediate
Used as a reactive intermediate in organic synthesis to introduce the 4-methylbenzylsulfonyl moiety. Its structure makes it valuable for derivatization reactions.
Organic Building Block
Serves as a versatile building block for constructing more complex organic molecules. It is part of the broader category of sulfonyl halides used in synthetic chemistry.
Research and Development
A reagent commonly utilised in academic and industrial research laboratories for exploring new synthetic pathways and developing novel compounds.
| Molecular weight | 204.67 |
|---|---|
| Linear formula | H3CC6H4CH2SO2Cl |
| Assay | 96% |
| Storage temperature | 2-8°C |
| Melting point | 76-80 °C |


Hazard statements
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 22-34 |
| Safety statements (S) | 26-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Methylbenzylsulfonyl chloride used for?
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4-Methylbenzylsulfonyl chloride is primarily used as a reactive intermediate and organic building block in chemical synthesis, particularly in research and development for introducing the 4-methylbenzylsulfonyl group.
What are the CAS number and chemical formula for 4-Methylbenzylsulfonyl chloride?
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The CAS number is 51419-59-1 and the linear chemical formula is H3CC6H4CH2SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Methylbenzylsulfonyl chloride with an assay of 96%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling precautions for 4-Methylbenzylsulfonyl chloride?
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This compound is classified as Danger, with hazards H302 (Harmful if swallowed) and H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment including eyeshields, face shields, gloves, and respiratory protection is essential. Handle with extreme care in a well-ventilated area.
How is 4-Methylbenzylsulfonyl chloride packaged and shipped?
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4-Methylbenzylsulfonyl chloride is shipped as UN 3261, Class 8, Packing Group II. Storage at 2-8°C is recommended. Tech Serve Solutions exports fine chemicals globally.
How can I request a sample or quote for 4-Methylbenzylsulfonyl chloride?
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Please contact our sales team via the website or by phone to request a sample or obtain a quotation for 4-Methylbenzylsulfonyl chloride.
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