4-Methylbenzylzinc chloride solution
4-Methylbenzylzinc chloride solution (CAS: 312693-21-3), with the linear formula CH3C6H4CH2ZnCl and a molecular weight of 206.00 g/mol, is a valuable organozinc halide reagent. Supplied as a 0.5 M solution in THF, this compound is primarily utilised in organic synthesis for carbon-carbon bond formation. Its reactivity makes it a key component in various cross-coupling reactions, enabling the construction of complex molecular architectures.
Organic Synthesis Reagent
4-Methylbenzylzinc chloride solution is extensively employed in organic synthesis, particularly in transition metal-catalysed cross-coupling reactions. It serves as a nucleophilic source of the 4-methylbenzyl group for the formation of new carbon-carbon bonds.
Cross-Coupling Reactions
This organozinc reagent is ideal for Negishi and other related coupling reactions. It facilitates the introduction of the 4-methylbenzyl moiety onto a variety of organic electrophiles, leading to more complex molecular structures.
Pharmaceutical Intermediate Synthesis
The compound can be used in the synthesis of complex organic molecules that may serve as intermediates in the development of pharmaceutical agents. Its controlled reactivity allows for selective functionalization in multi-step synthetic routes.
| Molecular weight | 206.00 |
|---|---|
| Linear formula | CH3C6H4CH2ZnCl |
| Density | 0.946 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-14-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Methylbenzylzinc chloride solution used for?
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4-Methylbenzylzinc chloride solution is primarily used as a reagent in organic synthesis, particularly for carbon-carbon bond formation via cross-coupling reactions like the Negishi coupling. It introduces the 4-methylbenzyl group into organic molecules.
What is the CAS number and formula for 4-Methylbenzylzinc chloride solution?
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The CAS number for 4-Methylbenzylzinc chloride solution is 312693-21-3. Its linear formula is CH3C6H4CH2ZnCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Methylbenzylzinc chloride solution at a concentration of 0.5 M in THF. The specific assay or purity is available upon request, and TSS does not represent this product as USP, BP, or EP grade.
How should 4-Methylbenzylzinc chloride solution be handled and stored?
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4-Methylbenzylzinc chloride solution is flammable and can cause serious eye irritation and respiratory irritation. It may also be a suspected carcinogen and can form explosive peroxides. Store at 2-8°C, away from ignition sources, and handle with appropriate personal protective equipment in a well-ventilated area.
Is 4-Methylbenzylzinc chloride solution shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and can export 4-Methylbenzylzinc chloride solution worldwide, adhering to all relevant shipping regulations.
How can I request a quote or sample?
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To request a quote or a sample of 4-Methylbenzylzinc chloride solution, please contact our sales department through the website or by phone, providing your contact details and requirements.
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