4-Hydroxyindole
4-Hydroxyindole (CAS: 2380-94-1, Formula: C8H7NO) is a heterocyclic organic compound with a molecular weight of 133.15 g/mol. This versatile building block finds application in the synthesis of various biologically active molecules. Its utility spans the development of potential treatments for diabetes, HIV, and cancer, as well as its use in creating novel imaging agents.
- IUPAC
- 4-Hydroxyindole,4-Indolol
SGLT2 Inhibitor Precursor
Serves as a reactant for preparing N-β-D-xylosyl-indole derivatives, investigated as SGLT2 inhibitors for the management of hyperglycemia in diabetes.
HIV-1 Integrase Interaction Modulators
Utilised in the synthesis of small molecules designed to target the interaction between HIV-1 integrase and the LEDGF/p75 cofactor.
Dopamine D2 Receptor Antagonist Synthesis
Employed as a reactant in the preparation of compounds targeting dopamine D2 receptors.
SCD Inhibitor MF-438 Intermediate
A key reactant in the synthetic route towards the stearoyl-CoA desaturase (SCD) inhibitor MF-438.
PET Imaging Agent Development
A reactant for the synthesis of carbon-11-labeled 4-aryl-4H-chromenes, developed as PET agents for imaging apoptosis in cancer.
HCV Inhibitor Synthesis
A reactant in the preparation of indole/quinoline carbothioic acid amide derivatives with potential as inhibitors of the Hepatitis C virus (HCV).
| Molecular weight | 133.15 |
|---|---|
| Empirical formula | C8H7NO |
| Assay | 99% |
| Application | • Reactant for preparation of N-β-D-xylosyl-indole derivatives as SGLT2 inhibitors for management of hyperglycemia in diabetes1• Reactant for preparation of small molecules targeting interaction between HIV-1 integrase and LEDGF/p75 cofactor2• Reactant for preparation of dopamine D2 receptor antagonists3• Reactant for preparation of SCD inhibitor MF-4384• Reactant for preparation of carbon-11-labeled 4-aryl-4H-chromenes as new PET agents for imaging of apoptosis in cancer5• Reactant for preparation of indole/quinoline carbothioic acid amide derivatives as HCV inhibitors6 |
| Melting point | 97-99 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Hydroxyindole used for?
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4-Hydroxyindole is used as a reactant and building block in the synthesis of various biologically active compounds, including potential treatments for diabetes, HIV, and cancer, as well as for developing PET imaging agents and other pharmaceutical intermediates.
What is the CAS number and formula for 4-Hydroxyindole?
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The CAS number for 4-Hydroxyindole is 2380-94-1, and its empirical formula is C8H7NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Hydroxyindole with an assay of 99%. This product is typically supplied for research and chemical synthesis purposes and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should 4-Hydroxyindole be handled safely?
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4-Hydroxyindole is classified as a Warning substance, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, should be used. Ensure good ventilation.
How is 4-Hydroxyindole packed and shipped by TSS?
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Tech Serve Solutions packs and exports chemicals according to international regulations to ensure safe transit. Specific packaging details depend on quantity and destination.
How can I request a sample or quote for 4-Hydroxyindole?
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To request a sample or obtain a quote for 4-Hydroxyindole, please contact the Tech Serve Solutions sales team via the website or listed contact details, specifying the product CAS number (2380-94-1).
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