4-Hydroxy-1-methyl-2(1H)-quinolone
4-Hydroxy-1-methyl-2(1H)-quinolone (CAS: 1677-46-9, C10H9NO2) is a heterocyclic organic compound with a molecular weight of 175.18. It serves as a valuable building block in chemical synthesis, particularly for creating complex quinoline derivatives. Its applications include acting as a nucleophile in electrochemical oxidation studies and participating in ceric ammonium nitrate-mediated cycloaddition reactions to form substituted dihydrofurans and related compounds.
Nucleophilic Reactions in Electrochemistry
This compound functions as a nucleophile in the electrochemical oxidation of catechols. This reaction pathway has been investigated using techniques such as cyclic voltammetry and controlled-potential coulometry.
Synthesis of Dihydrofuran Derivatives
It is employed in ceric ammonium nitrate-mediated oxidative cycloaddition reactions. These reactions are used to synthesise various substituted dihydrofurans, including dihydrofurans, dihydrofurocoumarins, dihydrofuropyrans, and dihydrofurophenalenones.
Precursor for Substituted Quinolones
4-Hydroxy-1-methyl-2(1H)-quinolone is utilised in the synthesis of specific substituted quinolinone derivatives, such as 3-(4-methoxybenzyl)-4-hydroxy-1-methylquinolinone and related compounds.
| Molecular weight | 175.18 |
|---|---|
| Empirical formula | C10H9NO2 |
| Assay | 98% |
| Application | 4-Hydroxy-1-methyl-2(1H)-quinolone was used as nucleophile in electrochemical oxidation of catechols and the reaction was studied by cyclic voltammetry and controlled-potential coulometry1. It was used in ceric ammonium nitrate-mediated oxidative cycloaddition of 1,3-dicarbonyls to conjugated compounds to yield substituted dihydrofurans, dihydrofurocoumarins, dihydrofuroquinolinones and dihydrofurophenalenones2. It was used in the synthesis of :• 3-(4-methoxybenzyl)-4-hydroxy-1-methylquinolinone3• 3-(benzo[d][1,3]dioxol-5-ylmethyl)-4-hydroxy-1-methylquinolin-2(1H)-one3• 3-(4-chlorobenzyl)-4-hydroxy-1-methylquinolin-2(1H)-one3• 3,3′-bis(4-chlorobenzylidene)-1,10-methylquinolin-2,20-(1H)-one3 |
| Melting point | 269-271 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Hydroxy-1-methyl-2(1H)-quinolone used for?
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4-Hydroxy-1-methyl-2(1H)-quinolone is used as a nucleophile in electrochemical oxidation studies and in ceric ammonium nitrate-mediated oxidative cycloaddition reactions for synthesising substituted dihydrofurans and related heterocyclic compounds.
What are the CAS number and formula for 4-Hydroxy-1-methyl-2(1H)-quinolone?
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The CAS number is 1677-46-9 and the empirical formula is C10H9NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Hydroxy-1-methyl-2(1H)-quinolone at an assay of 98%. This product is intended for research and laboratory use and is not supplied as USP, BP, EP, or pharmaceutical grade.
How should 4-Hydroxy-1-methyl-2(1H)-quinolone be handled safely?
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This compound is a Warning substance (GHS07) and may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (NIOSH N95), eyeshields, and gloves. Ensure good ventilation.
Is 4-Hydroxy-1-methyl-2(1H)-quinolone shipped internationally?
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Yes, Tech Serve Solutions specialises in global supply and export of fine chemicals, pharmaceutical intermediates, and laboratory reagents, including 4-Hydroxy-1-methyl-2(1H)-quinolone.
How can I request a quote or sample?
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To request a quote or sample for 4-Hydroxy-1-methyl-2(1H)-quinolone, please contact our sales team through the website or by phone.
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