4-Fluoro-2-(trifluoromethyl)phenyl isocyanate
4-Fluoro-2-(trifluoromethyl)phenyl isocyanate (CAS: 190774-54-0) is a valuable organic building block with the molecular formula FC6H3(CF3)NCO and a molecular weight of 205.11 g/mol. Its structure features both a fluorine atom and a trifluoromethyl group, making it useful in the synthesis of complex fluorinated organic compounds. This chemical is primarily employed in research and development settings within the pharmaceutical and agrochemical industries for the creation of novel active ingredients.
Pharmaceutical Intermediate
This isocyanate serves as a key intermediate in the synthesis of new pharmaceutical compounds. Its unique fluorinated structure can impart desirable properties to drug candidates, influencing factors like metabolic stability and bioavailability.
Agrochemical Synthesis
It is utilised in the development of advanced agrochemicals. The trifluoromethyl and fluoro substituents can enhance the efficacy and persistence of pesticides and herbicides.
Organic Synthesis Building Block
As a versatile building block, it is instrumental in constructing complex organic molecules. The reactive isocyanate group readily participates in various addition reactions for further chemical elaboration.
Materials Science Research
The compound may find application in materials science for the development of speciality polymers or functional materials where its fluorinated moiety can confer specific thermal or chemical resistance properties.
| Molecular weight | 205.11 |
|---|---|
| Linear formula | FC6H3(CF3)NCO |
| Assay | 97% |
| Boiling point | 52 °C/2.5 mmHg(lit.) |
| Density | 1.43 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.461(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H314Causes severe skin burns and eye damage
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 71 °C / 159.8 °F |
| Transport (UN / ADR) | UN 2922 8/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 20/21/22-34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluoro-2-(trifluoromethyl)phenyl isocyanate used for?
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4-Fluoro-2-(trifluoromethyl)phenyl isocyanate (CAS: 190774-54-0) is primarily used as a building block in organic synthesis, particularly in the development of novel pharmaceutical intermediates and agrochemicals.
What is the CAS number and formula for this compound?
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The CAS number is 190774-54-0 and the linear formula is FC6H3(CF3)NCO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 97%. This is a technical grade suitable for research and synthesis; it is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 4-Fluoro-2-(trifluoromethyl)phenyl isocyanate be handled safely?
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This compound is classified as corrosive and harmful if swallowed, inhaled, or in contact with skin. It causes severe skin burns and eye damage. Always handle with appropriate personal protective equipment, including gloves, eye protection, and respiratory protection, in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive handling guidelines.
Is this product shipped internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter, capable of shipping chemicals worldwide in compliance with international regulations.
How can I request a quote or sample?
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To request a quote or a sample, please contact our sales department through the website or by calling our main office. Provide the product name and CAS number for efficient processing.
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