4-(Dimethylamino)pyridine
4-(Dimethylamino)pyridine (CAS: 1122-58-3, C7H10N2) is a highly effective nucleophilic catalyst. With a molecular weight of 122.17 g/mol, it significantly accelerates acylation reactions, particularly esterifications and amidations. Commonly known as DMAP, this organic base is a valuable reagent in synthetic organic chemistry, frequently employed in laboratory research and development for its catalytic efficiency and versatility in promoting complex molecular transformations.
- IUPAC
- N,N-Dimethylpyridin-4-amine,DMAP
- Synonyms
- N,N-Dimethylpyridin-4-amineDMAP
Acylation Catalyst
4-(Dimethylamino)pyridine serves as a highly efficient catalyst for various acylation reactions, including esterification and amidation processes. Its strong nucleophilicity facilitates the transfer of acyl groups, leading to improved reaction rates and yields.
Organic Synthesis Reagent
As a versatile organic base, DMAP is widely used in general organic synthesis. It is instrumental in promoting reactions that require a strong nucleophilic catalyst, making it a staple in research and development laboratories.
Research and Development
This compound is supplied in development quantities for research purposes. It aids chemists in exploring new synthetic pathways and optimising existing methodologies in academic and industrial research settings.
| Molecular weight | 122.17 |
|---|---|
| Empirical formula | C7H10N2 |
| Assay | ≥99.0% (NT) |
| Grade | ReagentPlus® |
| Density | 0.884 g/mL at 25 °C |
| Refractive index | n20/D 1.417 |
| Solubility | methanol: soluble0.1 g/mL, clear |
| Melting point | 108-110 °C(lit.)111-114 °C |
| Concentration | 0.5 M in THF |
| Application | A highly efficient catalyst for acylation reactions |
Hazard statements
- H301Toxic if swallowed
- H310Fatal in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P302IF ON SKIN
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 110 °C / 230 °F |
| Transport (UN / ADR) | UN 2811 6.1 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 25-27-36/37/38 |
| Safety statements (S) | 26-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Dimethylamino)pyridine used for?
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4-(Dimethylamino)pyridine (DMAP) is primarily used as a highly efficient nucleophilic catalyst, particularly for acylation reactions such as esterifications and amidations. It is also a valuable reagent in general organic synthesis and research & development.
What is the CAS number and chemical formula for 4-(Dimethylamino)pyridine?
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The CAS number for 4-(Dimethylamino)pyridine is 1122-58-3, and its chemical formula is C7H10N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Dimethylamino)pyridine in a ReagentPlus® grade with an assay of ≥99.0% (NT). TSS does not represent this product as USP, BP, or EP grade.
How should 4-(Dimethylamino)pyridine be handled safely?
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4-(Dimethylamino)pyridine is classified as Danger with hazards including H301 (Toxic if swallowed), H310 (Fatal in contact with skin), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Always use appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, and handle in a well-ventilated area. Consult the Safety Data Sheet for detailed guidance.
How is 4-(Dimethylamino)pyridine packed and exported?
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Tech Serve Solutions professionally packs and exports chemicals globally, adhering to all relevant transportation and safety regulations. Specific packaging details are available upon request.
How can I request a sample or quote for 4-(Dimethylamino)pyridine?
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To request a sample or obtain a quote for 4-(Dimethylamino)pyridine, please contact our sales team through the website or by phone. Provide your specific requirements for prompt assistance.
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