4-Cyanophenylzinc bromide solution
4-Cyanophenylzinc bromide solution (CAS: 131379-14-1) is an organozinc halide reagent supplied by Tech Serve Solutions at 0.5 M in THF. With a molecular weight of 247.41 g/mol, this compound is valuable in organic synthesis. It is particularly useful for palladium-catalyzed cross-coupling reactions, enabling the formation of carbon-carbon bonds and the introduction of the 4-cyanophenyl moiety into complex molecules.
Suzuki-Miyaura Coupling Reactions
This organozinc reagent serves as an effective coupling partner in Suzuki-Miyaura reactions, facilitating the synthesis of biaryl compounds with a 4-cyanophenyl substituent.
Negishi Coupling Reactions
Utilised in Negishi coupling, 4-Cyanophenylzinc bromide solution enables the formation of new carbon-carbon bonds by coupling with organohalides.
Synthesis of Pharmaceutical Intermediates
Its ability to introduce the 4-cyanophenyl group makes it a key building block in the synthesis pathways for various pharmaceutical intermediates.
Material Science Applications
The 4-cyanophenyl moiety can be incorporated into advanced materials, leveraging the properties conferred by the cyano and phenyl groups.
| Molecular weight | 247.41 |
|---|---|
| Linear formula | NCC6H4ZnBr |
| Density | 0.98 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-14-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Cyanophenylzinc bromide solution used for?
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4-Cyanophenylzinc bromide solution is primarily used in organic synthesis, particularly in palladium-catalyzed cross-coupling reactions like Suzuki-Miyaura and Negishi couplings, to introduce the 4-cyanophenyl group into organic molecules.
What is the CAS number and formula for 4-Cyanophenylzinc bromide solution?
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The CAS number is 131379-14-1, and the linear formula is NCC<sub>6</sub>H<sub>4</sub>ZnBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Cyanophenylzinc bromide solution at a concentration of 0.5 M in THF. As this is a reagent for chemical synthesis, TSS does not represent it as USP, BP, EP, or any other pharmacopoeial grade.
How should 4-Cyanophenylzinc bromide solution be handled and stored?
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This solution is flammable (flash point -17 °C) and may form explosive peroxides. It is also an irritant to the eyes and respiratory system and is suspected of causing cancer. Store at 2-8°C and handle with appropriate personal protective equipment in a well-ventilated area, away from ignition sources. Follow P210, P261, P281, and P305 + P351 + P338 precautionary statements.
Is 4-Cyanophenylzinc bromide solution a controlled substance?
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The provided data does not indicate that 4-Cyanophenylzinc bromide solution is a controlled substance.
How is 4-Cyanophenylzinc bromide solution packed, shipped, and exported?
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This product is shipped under UN 2924 regulations (Hazard Class 8(3), Packing Group II). Tech Serve Solutions, established in 1998, is experienced in the global export of fine chemicals and laboratory reagents.
How can I request a sample or quote for 4-Cyanophenylzinc bromide solution?
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Please contact our sales team via the website or direct email to request a sample or a formal quotation for 4-Cyanophenylzinc bromide solution.
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