4-Cyanophenylboronic acid
4-Cyanophenylboronic acid (CAS: 126747-14-6, Formula: NCC6H4B(OH)2, MW: 146.94) is a valuable organoboron compound utilised in organic synthesis. It serves as a key reactant in various transformations, including oxidative hydroxylation, trifluoromethylation, and 1,4-addition reactions. Furthermore, it acts as a precursor in the development of important pharmaceutical intermediates, such as Tpl2 kinase inhibitors and P2X7 antagonists.
- IUPAC
- (p-Cyanophenyl)boronic acid,4-Cyanobenzeneboronic acid,4-Cyanophenylboric acid
- Synonyms
- (p-Cyanophenyl)boronic acid4-Cyanobenzeneboronic acid4-Cyanophenylboric acid
Organometallic Synthesis
4-Cyanophenylboronic acid is employed as a reactant in diverse synthetic methodologies, notably oxidative hydroxylation, trifluoromethylation, and 1,4-addition reactions.
Pharmaceutical Intermediate Synthesis
This boronic acid derivative serves as a crucial precursor for the synthesis of complex molecules, including inhibitors for Tpl2 kinase and antagonists for P2X7 receptors, which are targets for pain management.
Chemical Building Block
As an aryl boronic acid, it is a versatile building block in cross-coupling reactions and other C-C bond-forming processes within medicinal chemistry and materials science.
| Molecular weight | 146.94 |
|---|---|
| Linear formula | NCC6H4B(OH)2 |
| Application | Reactant involved in:• Oxidative hydroxylation1• Trifluoromethylation2• 1,4-Addition reactions3Precursor in the synthesis of inhibitors such as:• Tpl2 kinase inhibitors4• P2X7 antagonists used in the treatment of pain5 |
| Melting point | >350 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Cyanophenylboronic acid used for?
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4-Cyanophenylboronic acid is used as a reactant in oxidative hydroxylation, trifluoromethylation, and 1,4-addition reactions. It also serves as a precursor in the synthesis of Tpl2 kinase inhibitors and P2X7 antagonists.
What is the CAS number and chemical formula for 4-Cyanophenylboronic acid?
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The CAS number is 126747-14-6 and the chemical formula is NCC6H4B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Cyanophenylboronic acid as a technical/research grade chemical. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
What are the safety precautions for handling 4-Cyanophenylboronic acid?
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When handling 4-Cyanophenylboronic acid, it is essential to wear eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if airborne exposure is possible. Refer to the Safety Data Sheet for comprehensive handling information.
Is 4-Cyanophenylboronic acid a controlled substance?
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Based on the provided data, 4-Cyanophenylboronic acid is not listed as a controlled substance.
How can I request a quote or sample for 4-Cyanophenylboronic acid?
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To request a quote or sample of 4-Cyanophenylboronic acid, please contact our sales team through the website or by phone.
Can Tech Serve Solutions export 4-Cyanophenylboronic acid?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents, including 4-Cyanophenylboronic acid.
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