4-Chlorophenylmagnesium bromide solution
4-Chlorophenylmagnesium bromide solution (CAS: 873-77-8; ClC6H4MgBr; MW: 215.76) is a versatile organometallic reagent supplied by Tech Serve Solutions. This solution, typically 1.0 M in 2-methyltetrahydrofuran, is primarily utilised in organic synthesis for introducing the 4-chlorophenyl group via Grignard reactions. Its reactivity makes it a valuable tool in the construction of complex organic molecules for research and development.
Grignard Reagent in Organic Synthesis
4-Chlorophenylmagnesium bromide serves as a nucleophile in Grignard reactions, enabling the formation of carbon-carbon bonds. It reacts with various electrophiles such as aldehydes, ketones, esters, and epoxides to yield functionalised aromatic compounds.
Synthesis of Pharmaceutical Intermediates
This reagent can be employed in the multi-step synthesis of complex organic molecules, including potential pharmaceutical intermediates. The introduction of the 4-chlorophenyl moiety is a common strategy in drug discovery and development.
Preparation of Agrochemicals and Fine Chemicals
The 4-chlorophenyl group is present in numerous agrochemicals and other fine chemicals. 4-Chlorophenylmagnesium bromide provides a direct route for incorporating this structural unit during chemical manufacturing processes.
| Molecular weight | 215.76 |
|---|---|
| Linear formula | ClC6H4MgBr |
| Density | 1.005 g/mL at 25 °C |
| Concentration | 1.0 M in 2-methyltetrahydrofuran |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | -13 °C / 8.6 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-19-34 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chlorophenylmagnesium bromide solution used for?
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4-Chlorophenylmagnesium bromide solution is primarily used as a Grignard reagent in organic synthesis to introduce the 4-chlorophenyl group into target molecules. It is valuable for forming carbon-carbon bonds and is applied in the synthesis of pharmaceutical intermediates and fine chemicals.
What is the CAS number and formula for 4-Chlorophenylmagnesium bromide solution?
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The CAS number is 873-77-8, and the linear formula is ClC6H4MgBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this reagent as a 1.0 M solution in 2-methyltetrahydrofuran. TSS does not represent this product as USP, BP, or EP grade.
How should 4-Chlorophenylmagnesium bromide solution be handled and stored?
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This solution is flammable and corrosive, reacting violently with water. It should be handled with appropriate personal protective equipment in a well-ventilated area, away from ignition sources. Store under an inert atmosphere at 2-8°C. May form explosive peroxides.
How is this product shipped and exported?
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This product is classified under UN 2924, Hazard Class 8(3), Packing Group II. TSS is experienced in exporting chemicals globally, adhering to all relevant transportation regulations.
How can I request a quote or sample?
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Please contact our sales team via the website or direct email to request a quote or inquire about obtaining a sample of 4-Chlorophenylmagnesium bromide solution.
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