4-Chlorophenylboronic acid pinacol ester
4-Chlorophenylboronic acid pinacol ester (CAS 195062-61-4) is an organoboron compound with the molecular formula C12H16BClO2 and a molecular weight of 238.52 g/mol. This aryl boronate ester is a valuable building block in organic synthesis, frequently employed in cross-coupling reactions like the Suzuki-Miyaura coupling. It serves as a key intermediate for introducing the 4-chlorophenyl moiety into complex molecular structures, facilitating the development of pharmaceuticals and advanced materials.
- IUPAC
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)chlorobenzene
- Synonyms
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)chlorobenzene
Suzuki-Miyaura Coupling Reagent
This compound is widely utilized as a coupling partner in Suzuki-Miyaura reactions, enabling the formation of carbon-carbon bonds. It is essential for synthesising biaryl compounds and other complex organic molecules.
Pharmaceutical Intermediate
The 4-chlorophenyl group is a common structural motif in many active pharmaceutical ingredients (APIs). This boronate ester facilitates the introduction of this group during the synthesis of novel drug candidates and existing therapeutics.
Materials Science
It can be incorporated into polymers and advanced materials through cross-coupling methodologies, contributing to the development of organic electronic materials or specialised polymers with tailored properties.
Organic Synthesis Building Block
Beyond specific named reactions, this versatile compound acts as a general building block in complex organic synthesis, allowing chemists to construct intricate molecular architectures.
| Molecular weight | 238.52 |
|---|---|
| Empirical formula | C12H16BClO2 |
| Assay | 97% |
| Storage temperature | 2-8°C |
| Melting point | 50-55 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H413May cause long-lasting harmful effects to aquatic life
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chlorophenylboronic acid pinacol ester used for?
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4-Chlorophenylboronic acid pinacol ester is primarily used as a reagent in Suzuki-Miyaura cross-coupling reactions to introduce the 4-chlorophenyl group into organic molecules. It is a valuable intermediate in the synthesis of pharmaceuticals, agrochemicals, and materials science compounds.
What is the CAS number and molecular formula?
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The CAS number is 195062-61-4, and the molecular formula is C12H16BClO2. The molecular weight is 238.52 g/mol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Chlorophenylboronic acid pinacol ester with an assay of 97%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should 4-Chlorophenylboronic acid pinacol ester be handled and stored?
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This compound is classified as harmful if swallowed and may cause long-lasting harmful effects to aquatic life (H302, H413). It requires handling with a dust mask (type N95 US), eyeshields, and gloves. Store at 2-8°C.
How are Tech Serve Solutions' chemicals packed and shipped?
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Tech Serve Solutions packages chemicals securely for domestic and international export, adhering to all relevant shipping regulations. Specific packaging details depend on the quantity and destination.
How can I request a quote or sample?
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To request a quote or a sample of 4-Chlorophenylboronic acid pinacol ester, please contact our sales team through the website or by calling our main office. Please include the product name and CAS number.
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