4-Chlorobenzenesulfonyl chloride
4-Chlorobenzenesulfonyl chloride (CAS: 98-60-2; Formula: ClC6H4SO2Cl) is a key organic building block with a molecular weight of 211.07 g/mol. This sulfur compound, classified as a sulfonyl halide, is primarily utilised in chemical synthesis. Its reactivity makes it a valuable intermediate for creating more complex molecules in various research and development settings.
Synthesis of Tetrahydroquinoline and Pyrrolidine Carbamates
4-Chlorobenzenesulfonyl chloride serves as a reagent in the synthesis of novel tetrahydroquinoline sulfonamide carbamates and pyrrolidine sulfonamide carbamates, contributing to the development of new chemical entities.
Preparation of Piperazine Derivatives
It is employed in the synthesis of specific piperazine derivatives, such as 1-[bis-(4-fluorophenyl)-methyl]-4-(4-chlorobenzenesulfonyl)piperazine, demonstrating its utility in constructing complex heterocyclic structures.
Chiral Sulfinate Preparation
The compound is utilised in the Sharpless method for the preparation of chiral sulfinates, an important class of compounds in asymmetric synthesis and medicinal chemistry.
| Molecular weight | 211.07 |
|---|---|
| Linear formula | ClC6H4SO2Cl |
| Assay | ≥97.0% (GC) |
| Boiling point | 141 °C/15 mmHg(lit.) |
| Application | 4-Chlorobenzenesulfonyl chloride has been used:• in the synthesis of tetrahydroquinoline sulfonamide carbamates and pyrrolidine sulfonamide carbamates1• in the synthesis of 1-[bis-(4-fluorophenyl)-methyl]-4-(4-chlorobenzenesulfonyl)piperazine2• in Sharpless method for the preparation of chiral sulfinates by triphenylphosphine3 |
| Melting point | 50-52 °C(lit.)50-52 °C |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 108 °C / 226.4 °F |
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-37 |
| Safety statements (S) | 26-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chlorobenzenesulfonyl chloride used for?
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4-Chlorobenzenesulfonyl chloride is used in chemical synthesis, including the preparation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates, specific piperazine derivatives, and chiral sulfinates.
What are the CAS number and formula for 4-Chlorobenzenesulfonyl chloride?
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The CAS number is 98-60-2 and the molecular formula is ClC6H4SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Chlorobenzenesulfonyl chloride with an assay of ≥97.0% (GC). This product is intended for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.
How should 4-Chlorobenzenesulfonyl chloride be handled?
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4-Chlorobenzenesulfonyl chloride is a Danger hazard (H314), causing severe skin burns and eye damage. Appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection, must be worn. Handle in a well-ventilated area.
How is 4-Chlorobenzenesulfonyl chloride shipped?
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4-Chlorobenzenesulfonyl chloride is classified under UN 3261, 8/PGII, indicating it is a corrosive solid, acidic, organic, n.o.s. It is packed and exported according to international shipping regulations for hazardous materials.
How can I request a quote or sample?
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To request a quote or a sample of 4-Chlorobenzenesulfonyl chloride, please contact our sales team through the website or by phone, providing your required quantity and shipping details.
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