4-Chloro-2-(trifluoromethyl)aniline
4-Chloro-2-(trifluoromethyl)aniline (CAS: 445-03-4) is an organic compound with the formula ClC6H3(CF3)NH2 and a molecular weight of 195.57 g/mol. This aniline derivative, featuring a trifluoromethyl group and a chlorine atom on the benzene ring, serves as a valuable building block in chemical synthesis. It is primarily utilised in the preparation of more complex organic molecules within research and development settings.
- IUPAC
- 2-Amino-5-chlorobenzotrifluoride,4-Chloro-α,α,α-trifluoro-o-toluidine
- Synonyms
- 2-Amino-5-chlorobenzotrifluoride4-Chloro-α,α,α-trifluoro-o-toluidine
Intermediate in Organic Synthesis
This compound acts as a key intermediate in the synthesis of various organic molecules. Its specific structure allows for further functionalisation in multi-step synthetic pathways, particularly in the development of novel compounds.
Precursor for Specialty Chemicals
4-Chloro-2-(trifluoromethyl)aniline is employed in the synthesis of specialised chemical entities, including potential pharmaceutical intermediates and agrochemical research compounds. Its reactive amine group and substituted aromatic ring offer versatile reaction capabilities.
Research and Development
Utilised in laboratory settings for research purposes, enabling chemists to explore new reaction methodologies and create novel chemical structures. Its presence in the building block category highlights its importance in R&D.
| Molecular weight | 195.57 |
|---|---|
| Linear formula | ClC6H3(CF3)NH2 |
| Assay | 97% |
| Boiling point | 66-67 °C/3 mmHg(lit.) |
| Density | 1.386 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.507(lit.) |
| Storage temperature | 2-8°C |
| Application | 4-Chloro-2-(trifluoromethyl)aniline was used in the synthesis of 2-amino-5-chloro 3-(trifluoromethyl)benzenethiol1. |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
- H373May cause damage to organs through prolonged exposure
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 95 °C / 203 °F |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-33-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chloro-2-(trifluoromethyl)aniline used for?
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4-Chloro-2-(trifluoromethyl)aniline is primarily used as a building block and intermediate in organic synthesis, particularly in research and development for creating new chemical entities.
What are the CAS number and formula for 4-Chloro-2-(trifluoromethyl)aniline?
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The CAS number is 445-03-4, and the chemical formula is ClC6H3(CF3)NH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Chloro-2-(trifluoromethyl)aniline with an assay of 97%. This product is intended for laboratory and research use; TSS does not represent it as USP, BP, or EP grade.
How should 4-Chloro-2-(trifluoromethyl)aniline be handled safely?
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This compound is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and serious eye irritation, and may cause respiratory irritation. It may also cause damage to organs through prolonged or repeated exposure. Always handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area. Refer to the Safety Data Sheet for full handling instructions.
Is 4-Chloro-2-(trifluoromethyl)aniline a controlled substance?
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The provided data does not indicate that 4-Chloro-2-(trifluoromethyl)aniline is a controlled substance.
How is 4-Chloro-2-(trifluoromethyl)aniline packed and exported?
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4-Chloro-2-(trifluoromethyl)aniline is stored at 2-8°C and is available for global export. Packaging details are provided upon request.
How can I request a sample or quote for 4-Chloro-2-(trifluoromethyl)aniline?
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To request a sample or quote, please contact the Tech Serve Solutions sales team via our website or direct inquiry channels.
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