4-Chloro-2-fluoroaniline
4-Chloro-2-fluoroaniline (CAS 57946-56-2), with the molecular formula ClC6H3(F)NH2 and a molecular weight of 145.56 g/mol, is a halogenated aromatic amine. This compound serves as a valuable building block in organic synthesis. Its utility lies primarily in the creation of more complex molecules, particularly within the pharmaceutical and agrochemical industries, due to the presence of both fluorine and chlorine substituents on the aniline ring.

Pharmaceutical Intermediate
4-Chloro-2-fluoroaniline is employed as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the introduction of specific functionalities crucial for drug discovery and development.
Agrochemical Synthesis
This chemical is utilised in the production of active ingredients for agrochemicals. The fluorinated and chlorinated aromatic moiety can impart desirable properties to pesticides and herbicides.
Organic Synthesis Building Block
As a versatile building block, 4-Chloro-2-fluoroaniline is frequently used in academic and industrial research for constructing novel organic molecules. It is particularly useful for introducing halogenated aniline fragments into target structures.
| Molecular weight | 145.56 |
|---|---|
| Linear formula | ClC6H3(F)NH2 |
| Assay | 98% |
| Density | 1.311 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.56(lit.) |

Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 99 °C / 210.2 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chloro-2-fluoroaniline used for?
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4-Chloro-2-fluoroaniline is primarily used as a building block in organic synthesis, particularly for the development of pharmaceuticals and agrochemicals. Its specific structure makes it valuable for introducing fluorinated and chlorinated aniline fragments into target molecules.
What is the CAS number and formula for 4-Chloro-2-fluoroaniline?
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The CAS number for 4-Chloro-2-fluoroaniline is 57946-56-2, and its molecular formula is ClC6H3(F)NH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Chloro-2-fluoroaniline with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 4-Chloro-2-fluoroaniline be handled?
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4-Chloro-2-fluoroaniline is a Warning substance and is harmful if swallowed, in contact with skin, or if inhaled. It also causes skin irritation, serious eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment, including safety glasses, face shield, gloves, and a suitable respirator, should be used. Handle in a well-ventilated area.
Is 4-Chloro-2-fluoroaniline a controlled substance?
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The provided data does not indicate that 4-Chloro-2-fluoroaniline is a controlled substance.
How is 4-Chloro-2-fluoroaniline packed and shipped?
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Tech Serve Solutions exports fine chemicals globally, adhering to all relevant shipping regulations. Packing details are available upon request.
How can I request a quote or sample?
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To request a quote or sample of 4-Chloro-2-fluoroaniline, please contact our sales team through the website or by phone.
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