4-Chloro-2,8-bis(trifluoromethyl)quinoline
4-Chloro-2,8-bis(trifluoromethyl)quinoline (CAS: 83012-13-9) is a halogenated heterocyclic compound with the molecular formula C11H4ClF6N and a molecular weight of 299.60 g/mol. This quinoline derivative serves as a valuable building block in organic synthesis. Its structure, featuring both a chlorine atom and two trifluoromethyl groups on the quinoline core, makes it a useful intermediate for creating more complex molecules, particularly in the fields of pharmaceutical research and materials science.
- Synonyms
- C11H4ClF6N4-Chloro-2,8-bis(trifluoromethyl)quinoline

Organic Synthesis Intermediate
This compound is utilised as a versatile building block in complex organic syntheses. The presence of reactive functional groups allows for diverse chemical transformations.
Pharmaceutical Research
As a halogenated heterocyclic, it can be incorporated into novel molecular structures for drug discovery and development. Its unique substitution pattern may confer specific biological activities.
Materials Science
The trifluoromethyl groups can influence the electronic and physical properties of materials. This makes it a potential component in the development of advanced materials.
| Molecular weight | 299.60 |
|---|---|
| Empirical formula | C11H4ClF6N |
| Assay | 97% |
| Melting point | 46-48 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chloro-2,8-bis(trifluoromethyl)quinoline used for?
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4-Chloro-2,8-bis(trifluoromethyl)quinoline (CAS: 83012-13-9) is primarily used as a building block in organic synthesis, with applications in pharmaceutical research and materials science.
What is the CAS number and formula for 4-Chloro-2,8-bis(trifluoromethyl)quinoline?
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The CAS number is 83012-13-9 and the empirical formula (in Hill notation) is C11H4ClF6N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Chloro-2,8-bis(trifluoromethyl)quinoline with an assay of 97%. We do not represent this product as meeting USP, BP, EP, or other pharmacopoeial standards.
How should 4-Chloro-2,8-bis(trifluoromethyl)quinoline be handled?
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Based on the safety data, this compound may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
Is this chemical controlled or scheduled?
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There is no information in the provided data to suggest that 4-Chloro-2,8-bis(trifluoromethyl)quinoline is a controlled or scheduled substance.
How is 4-Chloro-2,8-bis(trifluoromethyl)quinoline packed and shipped?
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This chemical is packed and shipped according to standard international regulations for chemical transport. Please contact us for specific export details.
How can I request a sample or quote for 4-Chloro-2,8-bis(trifluoromethyl)quinoline?
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You can request a sample or quote by contacting our sales team through the website or by directly calling our customer service department.
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