4-Aminoindole
4-Aminoindole (CAS 5192-23-4), with the molecular formula C8H8N2 and a molecular weight of 132.16 g/mol, is a key heterocyclic building block. This indole derivative is a valuable intermediate in organic synthesis. Its applications span the development of novel pharmaceutical agents, including inhibitors for bacterial thymidylate synthase, protein kinase C θ, and cyclooxygenase-2, as well as antagonists for transient receptor potential cation channel subfamily V member 1.
- IUPAC
- (Indol-4-yl)amine,4-Indolamine
- Synonyms
- (Indol-4-yl)amine4-Indolamine
Pharmaceutical Intermediate
Serves as a crucial reactant in the synthesis of diverse biologically active compounds, such as inhibitors of bacterial thymidylate synthase and protein kinase C θ. It is also used in developing mimetics of the anticancer agent Podophyllotoxin.
Drug Discovery Research
Utilised in the research and development of potential therapeutics targeting pathways like Hedgehog and receptors including serotonin transporter and 5-HT1A. It also features in the creation of TRPV1 antagonists and COX-2/LOX inhibitors.
Advanced Chemical Synthesis
Employed as a versatile building block for creating complex organic molecules, including indolic non-peptidic HIV protease inhibitors and potent αvβ3 antagonists, contributing to the field of heterocyclic chemistry.
| Molecular weight | 132.16 |
|---|---|
| Empirical formula | C8H8N2 |
| Assay | 97% |
| Application | Reactant for preparation of:• Inhibitors of bacterial thymidylate synthase1• Mimetics of non-alkaloid toxin lignan anticancer and antiviral agent Podophyllotoxin (PPT)2• Inhibitors of Gli1-mediated transcription in the Hedgehog pathway3• Protein kinase C θ (PKCθ) inhibitors4• Indolic non-peptidic HIV protease inhibitors5• Transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonists6• Cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors7• 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitors8• Short chain 4-substituted indoles as potent αvβ3 antagonist9• Ligands of serotonin transporter and 5-HT1A receptors10 |
| Melting point | 106-109 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Aminoindole used for?
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4-Aminoindole is primarily used as a reactant and building block in organic synthesis, particularly for the development of pharmaceutical agents and research into various biological pathways and targets.
What are the CAS number and molecular formula for 4-Aminoindole?
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The CAS number for 4-Aminoindole is 5192-23-4, and its molecular formula is C8H8N2.
What grade and purity does Tech Serve Solutions supply for 4-Aminoindole?
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Tech Serve Solutions supplies 4-Aminoindole with a minimum purity of 97%. This product is intended for research and chemical synthesis purposes and is not supplied as USP, BP, EP, or any other pharmacopoeia grade.
How should 4-Aminoindole be handled safely?
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4-Aminoindole is classified as a Warning substance, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust. In case of contact, rinse thoroughly with water.
Is 4-Aminoindole exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 4-Aminoindole.
How can I request a sample or quote for 4-Aminoindole?
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To request a sample or quote for 4-Aminoindole, please contact our sales team through the website or by phone.
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