4-Aminocarbonylphenylboronic acid
4-Aminocarbonylphenylboronic acid (CAS: 123088-59-5) is an organoboron compound with the linear formula (H₂NCO)C₆H₄B(OH)₂ and a molecular weight of 164.95 g/mol. This versatile aryl boronic acid serves as a key reactant in various cross-coupling reactions, including Suzuki-Miyaura, Sonogashira, and Buchwald-Hartwig couplings. It is instrumental in synthesising complex organic molecules, including biologically active compounds.
- IUPAC
- 4-Carbamoylbenzeneboronic acid,4-Carbamoylphenylboronic acid
- Synonyms
- 4-Carbamoylbenzeneboronic acid4-Carbamoylphenylboronic acid
Suzuki-Miyaura Cross-Coupling Reactions
Utilised in Suzuki-Miyaura reactions for the synthesis of substituted pyrene derivatives, aryl-substituted oxabenzindoles, methanobenzindoles, and 2-aminoimidazole triazoles. It also participates in three-component couplings with triflates and alkenes.
Synthesis of Biologically Active Molecules
Serves as a reactant in the synthesis of molecules with potential therapeutic applications, such as hybrid peptidomimetic molecules acting as STAT3 protein inhibitors and vasopressin V1B receptor antagonists.
Preparation of Kinase Inhibitors
Involved in the synthesis of (thienopyridine)caboxamides, which are investigated as CHK1 inhibitors.
| Molecular weight | 164.95 |
|---|---|
| Linear formula | (H2NCO)C6H4B(OH)2 |
| Storage temperature | 2-8°C |
| Application | Reactant involved in:• Suzuki-Miyaura, Sonogashira and Buchwald-Hartwig cross-coupling reactions for the synthesis of substituted pyrene derivatives1• Suzuki-Miyaura reactions for the synthesis of aryl-substituted oxabenzindoles and methanobenzindoles2 or 2-aminoimidazole triazoles3• Three-component coupling with triflates and alkenes4Reactant involved in synthesis of biologically active molecules including:• Hybrid peptidomimetic molecules as STAT3 protein inhibitors5• Vasopressin V1B receptor antagonists for use as antidepressants oand anxiolytics6• (Thienopyridine)caboxamides as CHK1 inhibitors7 |
| Melting point | 229-234 °C |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Aminocarbonylphenylboronic acid used for?
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4-Aminocarbonylphenylboronic acid is used as a reactant in Suzuki-Miyaura, Sonogashira, and Buchwald-Hartwig cross-coupling reactions for synthesising substituted pyrene derivatives, aryl-substituted heterocycles, and biologically active molecules such as STAT3 inhibitors and vasopressin V1B receptor antagonists.
What is the CAS number and linear formula for 4-Aminocarbonylphenylboronic acid?
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The CAS number is 123088-59-5 and the linear formula is (H₂NCO)C₆H₄B(OH)₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with a purity of >95% and we do not represent it as USP, BP, or EP grade. For specific lot purity, please refer to the Certificate of Analysis.
How should 4-Aminocarbonylphenylboronic acid be handled safely?
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4-Aminocarbonylphenylboronic acid is harmful if swallowed (H302). When handling, wear appropriate personal protective equipment, including eyeshields, gloves, and a dust mask type N95 (US). Store at 2-8°C.
Can this product be shipped internationally?
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Yes, Tech Serve Solutions exports fine chemicals globally, adhering to all relevant shipping regulations.
How can I request a quote or sample?
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To request a quote or a sample, please visit the product page on our website and use the designated request forms, or contact our sales team directly.
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