4-Amino-2-chloropyridine
4-Amino-2-chloropyridine (CAS 14432-12-3) is a halogenated aminopyridine building block with the molecular formula C5H5ClN2 and a molar mass of 128.56 g/mol. Supplied as a solid melting at about 90-94 °C, it combines a reactive ring chlorine with a free amino group, making it a versatile intermediate for chemical synthesis. It is used chiefly in the preparation of pharmaceutical intermediates, agrochemicals and functionalised heterocyclic compounds.
- Synonyms
- 4-Amino-2-chloropyridine2-Chloro-4-aminopyridine2-Chloropyridin-4-amine4-Amino-2-chloro pyridineCAS 14432-12-3
Pharmaceutical intermediate
Serves as a heterocyclic building block in the synthesis of pharmaceutical intermediates and active ingredient candidates. Its amino group and displaceable ring chlorine allow controlled elaboration of the pyridine core.
Cross-coupling and substitution chemistry
The 2-chloro substituent is a useful handle for palladium-catalysed cross-coupling and nucleophilic aromatic substitution, enabling carbon-carbon and carbon-heteroatom bond formation on the ring.
Aminopyridine scaffold construction
The free 4-amino group provides a site for acylation, sulfonylation, reductive amination and diazotisation, supporting the assembly of more complex aminopyridine derivatives and ligands.
Agrochemical and fine-chemical research
Used as an intermediate in agrochemical discovery and broader fine-chemical research where a difunctional pyridine scaffold is required.
Laboratory reagent for heterocyclic synthesis
Employed at research and process-development scale as a reagent for preparing fused and substituted heterocyclic systems based on the pyridine ring.
| Molecular weight | 128.56 |
|---|---|
| Empirical formula | C5H5ClN2 |
| Assay | 97% |
| Melting point | 90-94 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Amino-2-chloropyridine used for?
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It is used mainly as a synthetic building block for pharmaceutical intermediates, agrochemicals and functionalised heterocycles. The reactive 2-chloro position and 4-amino group make it well suited to cross-coupling, nucleophilic substitution and further derivatisation of the pyridine ring.
What is the CAS number and molecular formula of 4-Amino-2-chloropyridine?
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The CAS number is 14432-12-3 and the molecular formula is C5H5ClN2, corresponding to a molecular weight of 128.56 g/mol. The MDL number is MFCD00060089 and the EC number is 238-403-0.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Amino-2-chloropyridine at a typical assay of 97% as a technical/research grade reagent. We do not represent it as a USP, BP or EP pharmacopoeial grade. A current Certificate of Analysis is provided with each batch and specifications can be confirmed on request.
What are the safety and handling precautions for 4-Amino-2-chloropyridine?
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It is classified GHS07 with the signal word Warning. The hazard statements are H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Avoid breathing dust, wear gloves and eye protection, and if in eyes rinse cautiously with water for several minutes and remove contact lenses if present (P261, P305+P351+P338). It is assigned WGK 3 (German water-hazard class). Always refer to the Safety Data Sheet before use.
How is 4-Amino-2-chloropyridine packed, shipped and exported?
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It is supplied as a solid in securely sealed, labelled containers sized from research quantities to bulk, with packaging selected to protect the material in transit. Each consignment ships with a Certificate of Analysis and Safety Data Sheet, and Tech Serve Solutions handles export documentation and compliant international dispatch.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, and our team will respond with availability, lead time and a formal quotation. Samples can be arranged on request to support your evaluation and qualification.
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